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Alexandre Doussot
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 83
Citations - 3467
Alexandre Doussot is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 18, co-authored 60 publications receiving 2497 citations.
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Journal ArticleDOI
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Bruno Costa-Silva,Nicole M. Aiello,Allyson J. Ocean,Swarnima Singh,Haiying Zhang,Basant Kumar Thakur,Basant Kumar Thakur,Annette Becker,Ayuko Hoshino,Milica Tesic Mark,Henrik Molina,Jenny Xiang,Tuo Zhang,Till Martin Theilen,Guillermo García-Santos,Caitlin Williams,Yonathan Ararso,Yujie Huang,Gonçalo Rodrigues,Tang-Long Shen,Knut Jørgen Labori,Inger Marie Bowitz Lothe,Elin H. Kure,Jonathan M. Hernandez,Alexandre Doussot,Saya H. Ebbesen,Paul M. Grandgenett,Michael A. Hollingsworth,Maneesh Jain,Kavita Mallya,Surinder K. Batra,William R. Jarnagin,Robert E. Schwartz,Irina Matei,Héctor Peinado,Ben Z. Stanger,Jacqueline Bromberg,David Lyden,David Lyden +38 more
TL;DR: It is shown that PDAC-derived exosomes induce liver pre-metastatic niche formation in naive mice and consequently increase liver metastatic burden and suggests that exosomal MIF primes the liver for metastasis and may be a prognostic marker for the development of PDAC liver metastasis.
Journal ArticleDOI
Postoperative Mortality after Liver Resection for Perihilar Cholangiocarcinoma: Development of a Risk Score and Importance of Biliary Drainage of the Future Liver Remnant
Jimme K. Wiggers,Bas Groot Koerkamp,Kasia P. Cieslak,Alexandre Doussot,David van Klaveren,Peter J. Allen,Marc G. Besselink,Olivier R. Busch,Michael I. D’Angelica,Ronald P. DeMatteo,Dirk J. Gouma,T. Peter Kingham,Thomas M. van Gulik,William R. Jarnagin +13 more
TL;DR: The mortality risk score for patients with resectable PHC can be used for patient counseling and identification of modifiable risk factors, which include FLR volume, FLR drainage status, and preoperative cholangitis.
Journal ArticleDOI
FOLFIRINOX Induction Therapy for Stage 3 Pancreatic Adenocarcinoma
Eran Sadot,Alexandre Doussot,Eileen M. O'Reilly,Maeve A. Lowery,Karyn A. Goodman,Richard K. G. Do,Laura H. Tang,Mithat Gonen,Michael I. D’Angelica,Ronald P. DeMatteo,T. Peter Kingham,William R. Jarnagin,Peter J. Allen +12 more
TL;DR: Nearly one third of the patients who had been initially identified as having stage 3 pancreatic carcinoma and had been treated with FOLFIRINOX responded radiographically and underwent tumor resection.
Journal ArticleDOI
Survival after resection of perihilar cholangiocarcinoma—development and external validation of a prognostic nomogram
B. Groot Koerkamp,B. Groot Koerkamp,Jimme K. Wiggers,Mithat Gonen,Alexandre Doussot,Peter J. Allen,Marc G. Besselink,Leslie H. Blumgart,O.R.C. Busch,M.I. D'Angelica,R. P. DeMatteo,D. J. Gouma,T.P. Kingham,T.M. van Gulik,William R. Jarnagin +14 more
TL;DR: The proposed nomogram to predict DSS after curative intent resection of PHC had a better prognostic accuracy than the AJCC staging system and can inform patients and physicians, guide shared decision making for adjuvant therapy, and stratify patients in future randomized, controlled trials.
Journal ArticleDOI
Survival Prediction in Pancreatic Ductal Adenocarcinoma by Quantitative Computed Tomography Image Analysis.
Marc A. Attiyeh,Jayasree Chakraborty,Alexandre Doussot,Liana Langdon-Embry,Shiana Mainarich,Mithat Gonen,Vinod P. Balachandran,Michael I. D’Angelica,Ronald P. DeMatteo,William R. Jarnagin,T. Peter Kingham,Peter J. Allen,Amber L. Simpson,Richard K. G. Do +13 more
TL;DR: Quantitative analysis of CT texture features is associated with overall survival, and two continuous survival prediction models for resected PDAC patients are presented.