Journal ArticleDOI
The role of estrogen in mood disorders in women
TLDR
The evidence for the role of hormonal fluctuations, specifically estrogen, in triggering depressive symptoms in a subgroup of women is summarized and the potential role of estrogen in triggering depression symptoms via its effects on the serotonergic system, brain-derived neurotrophic factor and Protein Kinase C is reviewed.Abstract:
Major depression is twice as common in women as men and depressive episodes appear to be more common in women with bipolar disorder. There is accumulating evidence that, in at least some women, reproductive-related hormonal changes may play a role in increasing the risk of depressive symptoms premenstrually, postpartum and in the perimenopausal period. In this review, the evidence for the role of hormonal fluctuations, specifically estrogen, in triggering depressive symptoms in a subgroup of women is summarized. In addition, the potential role of estrogen in triggering depressive symptoms via its effects on the serotonergic system, brain-derived neurotrophic factor and Protein Kinase C is reviewed.read more
Citations
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Implications of timing of maternal depressive symptoms for early cognitive and language development.
TL;DR: The current state of the research linking maternal depressed mood and children’s cognitive and language development during early childhood is described, including both the timing of maternal depression and the chronicity of mothers’ depression on children”s risk for Cognitive and language delays.
Journal ArticleDOI
Glycogen Synthase Kinase-3: a Putative Molecular Target for Lithium Mimetic Drugs
Todd D. Gould,Husseini K. Manji +1 more
TL;DR: Preclinical evidence supports the hypothesis that inhibition of GSK-3 may represent a target for lithium's mood-stabilizing properties, and a major effort is underway to develop novel, specific, G SKS-3 inhibitors.
Journal ArticleDOI
Association of Hormonal Contraception With Depression
TL;DR: Use of hormonal contraception, especially among adolescents, was associated with subsequent use of antidepressants and a first diagnosis of depression, suggesting depression as a potential adverse effect of hormonal contraceptive use.
Journal ArticleDOI
Prevalence of Low Sexual Desire and Hypoactive Sexual Desire Disorder in a Nationally Representative Sample of US Women
Suzanne L. West,Aimee A. D'Aloisio,Robert P. Agans,William D. Kalsbeek,Natalie N. Borisov,John M. Thorp +5 more
TL;DR: Prevalence of low sexual desire is elevated among surgically and naturally menopausal women vs premenopausal women, and distress about low desire appears to be more than twice as prevalent among surgery-bound women vs women in stable relationships, although the estimate is fairly imprecise.
Journal ArticleDOI
Sleep and emotional processing.
TL;DR: Evidence converges in indicating that lack of sleep significantly influences emotional reactivity, and the processing of emotionally salient information could mainly benefit from REM sleep, although some crucial aspects of sleep-dependent emotional modulation remain unclear.
References
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Journal ArticleDOI
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Ronald C. Kessler,Katherine A. McGonagle,Shanyang Zhao,Christopher B. Nelson,Michael R. Hughes,Suzann Eshleman,Hans-Ulrich Wittchen,Kenneth S. Kendler +7 more
TL;DR: The prevalence of psychiatric disorders is greater than previously thought to be the case, and morbidity is more highly concentrated than previously recognized in roughly one sixth of the population who have a history of three or more comorbid disorders.
Journal ArticleDOI
Sex and depression in the National Comorbidity Survey I: Lifetime prevalence, chronicity and recurrence
Ronald C. Kessler,Katherine A. McGonagle,Marvin S. Swartz,Dan G. Blazer,Christopher B. Nelson +4 more
TL;DR: Age of onset analysis shows that this sex difference begins in early adolescence and persists through the mid-50s and means that the higher prevalence of 12-month depression among women than men is largely due to women having a higher risk of first onset.
Journal ArticleDOI
Regulation of BDNF and trkB mRNA in Rat Brain by Chronic Electroconvulsive Seizure and Antidepressant Drug Treatments
TL;DR: The enhanced induction and prolonged expression of BDNF in response to chronic ECS and antidepressant drug treatments could promote neuronal survival, and protect neurons from the damaging effects of stress.
Journal ArticleDOI
A molecular and cellular theory of depression
TL;DR: These findings constitute the framework for an updated molecular and cellular hypothesis of depression, which posits that stress-induced vulnerability and the therapeutic action of antidepressant treatments occur via intracellular mechanisms that decrease or increase, respectively, neurotrophic factors necessary for the survival and function of particular neurons.
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