Journal ArticleDOI
The role of magnesium binders in chronic kidney disease.
TLDR
While short‐term or adjuvant use of magnesium carbonate appears safe and effective as a phosphate binder, more studies are needed to evaluate the long‐term effects on vascular calcification, bone histology, and mortality.Abstract:
Magnesium is predominantly an intracellular cation that plays a critical role in cellular physiology Serum levels are often slightly elevated in patients on chronic hemodialysis and older reports suggests that total body stores may also be increased, based on bone biopsies in patients treated with higher dialysate magnesium levels than are currently in use today Several studies have shown that magnesium, particularly in the form of magnesium carbonate, is an effective phosphate binder and can decrease patients' exposure to calcium Retrospective studies suggest that magnesium may prevent vascular calcification in dialysis patients, although this remains controversial and has not been evaluated prospectively Magnesium may reduce arrhythmias postoperatively and, while it may theoretically reduce arrhythmic death in dialysis patients, this hypothesis has never been tested While short-term or adjuvant use of magnesium carbonate appears safe and effective as a phosphate binder, more studies are needed to evaluate the long-term effects on vascular calcification, bone histology, and mortalityread more
Citations
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Journal ArticleDOI
Vascular Smooth Muscle Cell Differentiation to an Osteogenic Phenotype Involves TRPM7 Modulation by Magnesium
Augusto C. Montezano,Deborah Zimmerman,Hiba Yusuf,Dylan Burger,Andreia Z. Chignalia,Vishal Wadhera,Frank N. van Leeuwen,Rhian M. Touyz +7 more
TL;DR: New molecular insights are provided whereby magnesium could protect against VSMC calcification and osteogenic differentiation through increased/restored TRPM7 activity and increased expression of anticalcification proteins, including osteopontin, BMP-7, and matrix Gla protein.
Journal ArticleDOI
Magnesium metabolism in health and disease
TL;DR: Hypermagnesemia usually occurs in the setting of renal insufficiency and excessive Mg intake, and body excretion of Mg can be enhanced by use of saline diuresis, furosemide, or dialysis depending on the clinical situation.
Journal ArticleDOI
Clinical implications of disordered magnesium homeostasis in chronic renal failure and dialysis.
TL;DR: High Mg levels have been associated with impairment of myocardial contractility, intradialytic hemodynamic instability, and hypotension, and low Mg has been also linked to carotid intima‐media thickness, a marker of atherosclerotic vascular disease and a predictor of vascular events.
Journal ArticleDOI
Evaluation of calcium acetate/magnesium carbonate as a phosphate binder compared with sevelamer hydrochloride in haemodialysis patients: a controlled randomized study (CALMAG study) assessing efficacy and tolerability
Angel L.M. de Francisco,Michael Leidig,Adrian Covic,Markus Ketteler,Ewa Benedyk-Lorens,Gabriel Mircescu,Caecilia Scholz,Pedro Ponce,Jutta Passlick-Deetjen +8 more
TL;DR: CaMg was non-inferior to the comparator at controlling serum phosphorus levels at Week 25, and had a good tolerability profile and thus may represent an effective treatment of hyperphosphataemia.
Journal ArticleDOI
Pharmacology, efficacy and safety of oral phosphate binders
TL;DR: The role of phosphate control in determining patient outcomes must be quantified, which is likely to require a large randomized, controlled study of two levels of phosphate controlled by Oral phosphate binders.
References
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Journal ArticleDOI
Intestinal absorption of magnesium from food and supplements.
TL;DR: In this article, the authors measured the intake of normal subjects after they ingested a standard meal supplemented with 0, 10, 20, 40, and 80mEq of magnesium acetate.
Journal ArticleDOI
Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease
Michael Shechter,Michael Sharir,Maura J. Paul Labrador,James S. Forrester,Burton B. Silver,C. Noel Bairey Merz +5 more
TL;DR: Oral magnesium therapy in CAD patients is associated with significant improvement in brachial artery endothelial function and exercise tolerance, suggesting a potential mechanism by which magnesium could beneficially alter outcomes in CAD Patients.
Journal ArticleDOI
Chemical and physicochemical studies on the mineral deposits of the human atherosclerotic aorta
TL;DR: The mineral deposits of the human atherosclerotic aorta were prepared by a new method characterized by the use of mild conditions and showed to possess essentially the same chemical composition.
Journal ArticleDOI
Serum magnesium level and arterial calcification in end-stage renal disease.
TL;DR: Observations suggest that in end-stage renal disease hypermagnesemia may retard the development of arterial calcifications in patients being treated by continuous ambulatory peritoneal dialysis.
Journal ArticleDOI
Magnesium absorption in the human small intestine. Results in normal subjects, patients with chronic renal disease, and patients with absorptive hypercalciuria.
TL;DR: The results suggest that Mg absorption in the human is mediated by a transport process different from that which facilitates Ca absorption, and that normal MG absorption may be dependent on vitamin D.
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