The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats.
Danielle Diniz Vilela,Leonardo Gomes Peixoto,Renata Roland Teixeira,Nathalia Belele Baptista,Douglas Carvalho Caixeta,Adriele Vieira de Souza,Helen Lara Machado,Mariana Nunes Pereira,Robinson Sabino-Silva,Foued Salmen Espindola +9 more
TLDR
The results reveal that dual therapy with metformin and insulin promotes more benefits to oxidative stress control in muscle of hypoinsulinemic rats than insulinotherapy alone.Abstract:
Metformin can act in muscle, inhibiting the complex I of the electron transport chain and decreasing mitochondrial reactive oxygen species. Our hypothesis is that the inhibition of complex I can minimize damage oxidative in muscles of hypoinsulinemic rats. The present study investigated the effects of insulin and/or metformin treatment on oxidative stress levels in the gastrocnemius muscle of diabetic rats. Rats were rendered diabetic (D) with an injection of streptozotocin and were submitted to treatment with insulin (D+I), metformin (D+M), or insulin plus metformin (D+I+M) for 7 days. The body weight, glycemic control, and insulin resistance were evaluated. Then, oxidative stress levels, glutathione antioxidant defense system, and antioxidant status were analyzed in the gastrocnemius muscle of hypoinsulinemic rats. The body weight decreased in D+M compared to ND rats. D+I and D+I+M rats decreased the glycemia and D+I+M rats increased the insulin sensitivity compared to D rats. D+I+M reduced the oxidative stress levels and the activity of catalase and superoxide dismutase in skeletal muscle when compared to D+I rats. In conclusion, our results reveal that dual therapy with metformin and insulin promotes more benefits to oxidative stress control in muscle of hypoinsulinemic rats than insulinotherapy alone.read more
Citations
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Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis.
Pan Luo,Lin Qiu,Yi Liu,Xiu Lan Liu,Jian Ling Zheng,Hui Ying Xue,Wen Hua Liu,Dong Liu,Juan Li +8 more
TL;DR: A retrospective analysis suggests that metformin may offer benefits in patients with COVID-19 and that further study is indicated.
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The Role of Oxidative Stress in Physiopathology and Pharmacological Treatment with Pro- and Antioxidant Properties in Chronic Diseases.
TL;DR: The involvement of OS in the pathological mechanisms of some chronic diseases, the pro- or antioxidant effects of their pharmacological treatments, and possible adjuvant antioxidant alternatives are discussed.
Journal ArticleDOI
Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights.
Ntsoaki Annah Nyane,Thabiso Bethwel Tlaila,Tanki Gabriel Malefane,Dudu Edith Ndwandwe,Peter M. O. Owira +4 more
TL;DR: Naringenin is evaluated as anti-diabetic, anti-dyslipidemic anti-inflammatory and antineoplastic agent similar to metformin and its further development for therapeutic use in clinical practice is proposed.
Journal ArticleDOI
Metformin and its anti-inflammatory and anti-oxidative effects; new concepts
TL;DR: All evidence suggests the antioxidant and anti-inflammatory role of metformin in various conditions, which inflammatory processes and oxidative stress play a role in their pathogenesis.
Journal ArticleDOI
Metformin-induced endocrine disruption and oxidative stress of Oryzias latipes on two-generational condition.
Jin Wuk Lee,Yu-jin Shin,Hokyun Kim,Heejung Kim,Jieun Kim,Su-A Min,Pilje Kim,Seung Do Yu,Kyunghwa Park +8 more
TL;DR: It is demonstrated that metformin leads to oxidative stress and two-generation endocrine disruption in O. latipes, and may be useful for better understanding met formin toxicity mechanism.
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