The Therapeutic Potential of Naringenin: A Review of Clinical Trials.
Bahare Salehi,Patrick Valere Tsouh Fokou,Mehdi Sharifi-Rad,Paolo Zucca,Raffaele Pezzani,Natália Martins,Javad Sharifi-Rad,Javad Sharifi-Rad +7 more
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TLDR
The currently available data are very promising, but further research on pharmacokinetic and pharmacodynamic aspects is encouraged to improve both available production and delivery methods and to achieve feasible naringenin-based clinical formulations.Abstract:
Naringenin is a flavonoid belonging to flavanones subclass. It is widely distributed in several Citrus fruits, bergamot, tomatoes and other fruits, being also found in its glycosides form (mainly naringin). Several biological activities have been ascribed to this phytochemical, among them antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic and cardioprotective effects. Nonetheless, most of the data reported have been obtained from in vitro or in vivo studies. Although some clinical studies have also been performed, the main focus is on naringenin bioavailability and cardioprotective action. In addition, these studies were done in compromised patients (i.e., hypercholesterolemic and overweight), with a dosage ranging between 600 and 800 μM/day, whereas the effect on healthy volunteers is still debatable. In fact, naringenin ability to improve endothelial function has been well-established. Indeed, the currently available data are very promising, but further research on pharmacokinetic and pharmacodynamic aspects is encouraged to improve both available production and delivery methods and to achieve feasible naringenin-based clinical formulations.read more
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Polyphenols: A concise overview on the chemistry, occurrence, and human health
Alessandra Durazzo,Massimo Lucarini,Eliana B. Souto,Eliana B. Souto,Carla Cicala,Elisabetta Caiazzo,Angelo A. Izzo,Ettore Novellino,Antonello Santini +8 more
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Potential Inhibitor of COVID-19 Main Protease (M pro ) From Several Medicinal Plant Compounds by Molecular Docking Study
TL;DR: Assessing bioactive compounds found in medicinal plants as potential COVID-19 Mpro inhibitors, using a molecular docking study, found nelfinavir and lopinavir may represent potential treatment options, and kaempferol, quercetin, luteolin-7-glucoside, demethoxycurcumin, naringenin, apigenin- 7-gl Sucoside appeared to have the best potential to act as COV inhibitors.
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Naringenin, a flavanone with antiviral and anti-inflammatory effects: A promising treatment strategy against COVID-19.
TL;DR: It is concluded that naringenin may be a promising treatment strategy against COVID‐19, a novel flu‐like coronavirus recognized by World Health Organization at the end of 2019.
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Engineering 4-coumaroyl-CoA derived polyketide production in Yarrowia lipolytica through a β-oxidation mediated strategy
TL;DR: This work enables high-level de novo production of naringenin through import of both a heterologous pathway and a mutant Y. lipolytica allele, and generates an averaged maximum titer of 898 mg/L, the highest titer reported to date in any host.
Journal ArticleDOI
Naringenin and naringin in cardiovascular disease prevention: A preclinical review
Reza Heidary Moghaddam,Zeinab Samimi,Seyed Zachariah Moradi,Peter J. Little,Suowen Xu,Mohammad Hosein Farzaei +5 more
TL;DR: The data collected in this review may serve as a comprehensive reference for the effects of naringin, and naringenin in cardiovascular disease, which may be beneficial for further research and for the design of naredin and naredenin analogs as new therapeutic options for cardiovascular diseases.
References
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Paul Knekt,Jorma Kumpulainen,Ritva Järvinen,Harri Rissanen,Markku Heliövaara,Antti Reunanen,Timo Hakulinen,Arpo Aromaa +7 more
TL;DR: The risk of some chronic diseases may be lower at higher dietary flavonoid intakes, and a trend toward a reduction in risk of type 2 diabetes was associated with higher quercetin intakes.
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Plasma Kinetics and Urinary Excretion of the Flavanones Naringenin and Hesperetin in Humans after Ingestion of Orange Juice and Grapefruit Juice
TL;DR: It is concluded that because of the relatively high concentrations of flavanones in plasma after ingestion of orange juice or grapefruit juice, considerable health effects could ensue in individuals consuming them regularly.
Journal ArticleDOI
Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).
TL;DR: It is shown that the concept of PAINS is relevant to compounds of natural origin, but that the context of the biological readout is an important factor that must be brought into consideration.
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De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae
Frank Koopman,Jules Beekwilder,Barbara Crimi,Adèle van Houwelingen,Robert Hall,Dirk Bosch,Antonius J. A. van Maris,Jack T. Pronk,Jean-Marc Daran +8 more
TL;DR: The results reported in this study demonstrate that S. cerevisiae is capable of de novo production of naringenin by coexpressing the naringENin production genes from A. thaliana and optimization of the flux towards the naredenin pathway.
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Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects.
TL;DR: Oral administration of the flavanone aglycones, hesperetin and naringenin, lead to their rapid absorption as their conjugated forms, and cumulative urinary recovery data indicated low bioavailability for both flavanones.