The TIMI risk score for unstable angina/non–ST-elevation MI: a method for prognostication and therapeutic decision making

TLDR: Many attempts to estimate a gradient of risk among patients with UA/NSTEMI focus on a single variable, such as presence or absence of electrocardiographic (ECG) changes or elevated serum cardiac markers.

Abstract: PATIENTS PRESENTING WITH AN acute coronary syndrome without ST-segment elevation are diagnosed as having unstable angina/non–ST elevation myocardial infarction (MI) (UA/NSTEMI). Given the heterogeneous nature of UA/ NSTEMI, such patients have a wide spectrum of risk for death and cardiac ischemic events. Many attempts to estimate a gradient of risk among patients with UA/NSTEMI focus on a single variable, such as presence or absence of electrocardiographic (ECG) changes or elevated serum cardiac markers. Prognostication schemes have been developed that categorize patients qualitatively into high, intermediate, or low risk, but they do not provide a quantitative statement about finer gradations of risk that exist clinically. Although univariate analyses are informative as an initial assessment of the importance of a potential prognos-