The use of leucocyte and platelet-rich fibrin in socket management and ridge preservation: a split-mouth, randomized, controlled clinical trial.
Andy Temmerman,Jeroen Vandessel,Ana B. Castro,Reinhilde Jacobs,Wim Teughels,Nelson Pinto,Marc Quirynen +6 more
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TLDR
The use of L-PRF as a socket filling material to achieve preservation of horizontal and vertical ridge dimension at three months after tooth extraction is beneficial.Abstract:
Aim
To investigate the influence of the use L-PRF as a socket filling material and its ridge preservation properties.
Materials and Methods
Twenty-two patients in need of single bilateral and closely symmetrical tooth extractions in the maxilla or mandible were included in a split-mouth RCT. Treatments were randomly assigned (L-PRF socket filling versus natural healing). CBCT scans were obtained after tooth extraction and three months. Scans were evaluated by superimposition using the original DICOM data. Mean ridge width differences between timepoints were measured at three levels below the crest on both the buccal and lingual sides (crest −1 mm (primary outcome variable), −3 mm and −5 mm).
Results
Mean vertical height changes at the buccal were −1.5 mm (±1.3) for control sites and 0.5 mm (±2.3) for test sites (p < 0.005). At the buccal side, control sites values were, respectively, −2.1 (±2.5), −0.3 mm (±0.3) (p < 0.005) and −0.1 mm (±0.0), and test sites values were, respectively, −0.6 mm (±2.2) (p < 0.005), −0.1 mm (±0.3) and 0.0 mm (±0.1). Significant differences (p < 0.005) were found for total width reduction between test (−22.84%) and control sites (−51.92%) at 1 mm below crest level. Significant differences were found for socket fill (visible mineralized bone) between test (94.7%) and control sites (63.3%).
Conclusion
The use of L-PRF as a socket filling material to achieve preservation of horizontal and vertical ridge dimension at three months after tooth extraction is beneficial.read more
Citations
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Effect of alveolar ridge preservation interventions following tooth extraction: A systematic review and meta-analysis.
TL;DR: The results of a pooled quantitative analysis revealed that ARP via socket grafting (ARP-SG), as compared to tooth extraction alone, prevents horizontal ridge preservation and whether there is a superior ARP or SS approach could not be determined on the basis of the selected evidence.
Journal ArticleDOI
Interventions for replacing missing teeth: alveolar ridge preservation techniques for dental implant site development.
Momen A. Atieh,Nabeel H.M. Alsabeeha,Alan G. T. Payne,Warwick J. Duncan,Clovis Mariano Faggion,Marco Esposito +5 more
TL;DR: The clinical effects of various materials and techniques for ARP after tooth extraction compared with extraction alone or other methods of ARP, or both, in patients requiring dental implant placement following healing of extraction sockets are assessed.
Journal ArticleDOI
Systematic Review and Meta-Analysis of Hard Tissue Outcomes of Alveolar Ridge Preservation.
Seyed Hossein Bassir,Muhanad Alhareky,Buddhathida Wangsrimongkol,Yinan Jia,Nadeem Y. Karimbux +4 more
TL;DR: Alveolar ridge preservation procedures are effective in minimizing postextraction hard tissue dimensional loss.
Journal ArticleDOI
Standardization of relative centrifugal forces in studies related to platelet-rich fibrin.
TL;DR: In this paper, the authors described necessary parameters pivotal for the future report of RCF in studies related to platelet-rich fibrin, which include: 1) dimensions of the rotor (radius at the clot and end of the tube); rotor angulation for the tube holder; 3) revolutions per minute (RPM) and time; 4) RCF value calculated at either the RCF-minimum, RCFclot, or RCFmax; 5) composition and size of tubes used to produce PRF; and 6) centrifugation model used.
Journal ArticleDOI
Fifteen Years of Platelet Rich Fibrin in Dentistry and Oromaxillofacial Surgery: How High is the Level of Scientific Evidence?
Shahram Ghanaati,Carlos Herrera-Vizcaino,Sarah Al-Maawi,Jonas Lorenz,Richard J. Miron,Katja Nelson,Frank Schwarz,Joseph Choukroun,Robert Sader +8 more
TL;DR: Evidence showed that PRF is a beneficial tool that significantly improves bone and soft tissue regeneration, however, the clinical community requires a standardization ofPRF protocols to further examine the benefit of PRF in bone andsoft tissue regeneration in reproducible studies, with a higher scientific level of evidence.
References
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Journal ArticleDOI
Platelet-rich plasma: Growth factor enhancement for bone grafts
Robert E. Marx,Eric R. Carlson,Ralph M. Eichstaedt,Ralph M. Eichstaedt,Steven R Schimmele,Steven R Schimmele,James E. Strauss,Karen R. Georgeff +7 more
TL;DR: Monoclonal antibody assessment of cancellous cellular marrow grafts demonstrated cells that were capable of responding to the growth factors by bearing cell membrane receptors and evidenced a radiographic maturation rate 1.62 to 2.16 times that of grafts without platelet-rich plasma.
Journal Article
Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study.
TL;DR: It was demonstrated that major changes of an extraction site occurred during 1 year after tooth extraction, and preservation of alveolar bone volume following tooth extraction facilitates subsequent placement of dental implants and leads to an improved esthetic and functional prosthodontic result.
Journal ArticleDOI
Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF).
TL;DR: This classification of the different platelet concentrates into four categories, depending on their leucocyte and fibrin content, should help to elucidate successes and failures that have occurred so far, as well as providing an objective approach for the further development of these techniques.
Journal ArticleDOI
Ridge alterations following implant placement in fresh extraction sockets: an experimental study in the dog.
TL;DR: Marked dimensional alterations had occurred in the edentulous ridge after 3 months of healing following the extraction of the distal root of mandibular pre-molars and it is suggested that the resorption of the socket walls that occurs following tooth removal must be considered in conjunction with implant placement in fresh extraction sockets.
Journal ArticleDOI
Ridge Preservation with Freeze-Dried Bone Allograft and a Collagen Membrane Compared to Extraction Alone for Implant Site Development: A Clinical and Histologic Study in Humans
John M. Iasella,Henry Greenwell,Richard L. Miller,Margaret Hill,Connie Drisko,Aziz A. Bohra,James P. Scheetz +6 more
TL;DR: Ridge preservation using FDBA and a collagen membrane improved ridge height and width dimensions when compared to extraction alone, and these dimensions may be more suitable for implant placement, especially in areas where loss of ridge height would compromise the esthetic result.