Journal ArticleDOI
The use of macrolide antibiotic substances in the treatment of asthma
Irving H. Itkin,Mark L. Menzel +1 more
TLDR
Infection could not be detected with any greater certainty in patients who responded to the macrolide than in those who did not, with the use of such criteria as the results of culture of the sputum for bacteria and mycoplasma.About:
This article is published in Journal of Allergy.The article was published on 1970-03-01. It has received 145 citations till now. The article focuses on the topics: Sputum & Erythromycin Estolate.read more
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Journal ArticleDOI
Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications
Soichiro Kanoh,Bruce K. Rubin +1 more
TL;DR: Macrolides have diverse biological activities and an ability to modulate inflammation and immunity in eukaryotes without affecting homeostatic immunity, which led to their long-term use in treating neutrophil-dominated inflammation in diffuse panbronchiolitis, bronchiectasis, rhinosinusitis, and cystic fibrosis.
Journal ArticleDOI
Pharmacokinetic Drug Interactions of Macrolides
TL;DR: These incriminated macrolide antibiotics should not be administered concomitantly with other drugs known to be affected metabolically by them, or at the very least, combined administration should be carried out only with careful patient monitoring.
Journal ArticleDOI
Anti-inflammatory activity of macrolides: a new therapeutic potential?
TL;DR: In-vitro data suggest that erythromycin A derivatives have a direct effect on neutrophil function and the production of cytokines involved in the inflammation cascade, and ex-vivo results indicate that short-term administration of macrolides may enhance the immune response while long- term administration results in immunosuppression.
Journal ArticleDOI
[Clinical effects of low-dose long-term erythromycin chemotherapy on diffuse panbronchiolitis].
Shoji Kudoh,Takeshi Uetake,Kouich Hagiwara,Masakiyo Hirayama,Lung-Hong Hus,Hitoshi Kimura,Yukihiko Sugiyama +6 more
Journal ArticleDOI
Macrolide antibacterials. Drug interactions of clinical significance.
N A von Rosensteil,D Adam +1 more
TL;DR: Macrolide antibiotics can interact adversely with commonly used drugs, usually by altering metabolism due to complex formation and inhibition of cytochrome P-450 IIIA4 in the liver and enterocytes, and through enhanced gastric emptying due to a motilin-like effect.
References
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Journal ArticleDOI
Drug-induced hepatic injury
Hans Popper,Fenton Schaffner +1 more
TL;DR: Excerpt Drug-induced hepatic injury poses many problems and establishment of a causal relation between a hepatic disease and preceding intake of a drug is often difficult.
Journal Article
The use of triacetyloleandomycin in chronic infectious asthma.
Kaplan Ma,Goldin M +1 more
Journal ArticleDOI
Hepatic dysfunction associated with triacetyloleandomycin and propionyl erythromycin ester lauryl sulfate.
Journal ArticleDOI
Serum glutamic oxalacetic transaminase. False elevations during administration of erythromycin.
TL;DR: Transient and sometimes marked elevations of serum glutamic oxalacetic transaminase were found in each of seven young adult male volunteers after oral administration of one or two courses of erythromycin estolate, and these elevations were shown to be due to an unidentified, trypsin-stable substance related to the administration of the antibiotic.
Journal Article
Antibiotics annual 1958-1959.
H. Welch,F. Marti-ibanez +1 more
TL;DR: Of all occupational neoplasms, 75% affect the skin and 15% the bladder, and nearly all the remaining 10% are found in the respiratory tract, so there are 18 known occupational causes of cancer including a relatively new one found inThe manufacture of isopropyl alcohol.