Journal ArticleDOI
Thrombokinetics in idiopathic thrombocytopenic purpura.
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Measurements of platelet production in 16 patients with idiopathic thrombocytopenic purpura demonstrate that megakaryocytopoiesis and platelet turnover are increased in parallel to as much as 8 times normal.Abstract:
Summary Measurements of platelet production in 16 patients with idiopathic thrombocytopenic purpura (ITP) demonstrate that megakaryocytopoiesis (total thrombopoiesis) and platelet turnover (effective thrombopoiesis) are increased in parallel to as much as 8 times normal. The marrow megakaryocytes show changes characteristic of stimulated thrombopoiesis.read more
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The bleeding time as a screening test for evaluation of platelet function.
TL;DR: The value of the standardized template bleeding time was studied in 100 normal subjects and 136 patients with various disorders and found that with normal platelets the bleeding time in this test is 4.5...
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Chronic idiopathic thrombocytopenic purpura.
TL;DR: ChristonIC idiopathic (or immune) thrombocytopenic purpura (ITP) is a syndrome characterized by persistent thrombinopathy caused by a circulating antiplatelet factor that results in platelet destruction by the reticuloendothelial system as mentioned in this paper.
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Platelet and Fibrinogen Consumption in Man
TL;DR: Survival and turnover measurements of platelets and fibrinogen in 35 normal subjects and 104 selected patients defined three types of consumptive processes involving the hemostatic apparatus.
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Autoimmune thrombocytopenic purpura
TL;DR: Adult autoimmune throbocytopenic purpura (ATP) is a platelet disorder that develops in certain individuals with a genetic as well as sex (female) predisposition following an environment event, which leads to the rapid clearance and destruction of opsonized platelets by the reticuloendothelial system, particularly the spleen.
Journal ArticleDOI
Quantitative determination of antibody in idiopathic thrombocytopenic purpura. Correlation of serum and platelet-bound antibody with clinical response.
TL;DR: Quantitation of surface IgG of thrombocytopenic platelets was useful in predicting response to treatment and correlated with failure to respond to prednisone therapy.
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Thrombokinetics in man
TL;DR: Platelet production, distribution, and destruction have been quantitated in normal man and in selected patients with platelet disorders and, in most instances, total production as calculated from the megakaryocyte mass agreed with production estimated from platelet turnover.
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Ferrokinetics in man.
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