Time-dependent relationship between the dorsal hippocampus and the prefrontal cortex in spatial memory.
Inah Lee,Raymond P. Kesner +1 more
TLDR
It is reported that the dorsal hippocampus and the medial prefrontal cortex process short-term spatial memory in parallel, serving as a compensatory mechanism for each other, indicating that the time window of memory is a key factor in dissociating multiple memory systems.Abstract:
The prefrontal cortex and the dorsal hippocampus have been studied extensively for their significant roles in spatial working memory. A possible time-dependent functional relationship between the prefrontal cortex and the dorsal hippocampus in spatial working memory was tested. A combined lesion and pharmacological inactivation technique targeting both the dorsal hippocampus and the medial prefrontal cortex was used (i.e., axon-sparing lesions of the dorsal hippocampus combined with reversible inactivation of the medial prefrontal cortex, or vice versa, within a subject). A delayed nonmatching-to-place task on a radial eight-arm maze with short-term (i.e., 10 sec) versus intermediate-term (i.e., 5 min) delays was used as a behavioral paradigm. Here we report that the dorsal hippocampus and the medial prefrontal cortex process short-term spatial memory in parallel, serving as a compensatory mechanism for each other. The role of the dorsal hippocampus, however, becomes highlighted as the time-window for memory (i.e., delay) shifts from short-term to a delay period (i.e., intermediate-term) exceeding the short-term range. The results indicate that the time window of memory is a key factor in dissociating multiple memory systems.read more
Citations
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Hippocampal Place Cells Show Increased Sensitivity to Changes in the Local Environment Following Prefrontal Cortex Lesions
Rachel J. Kyd,David K. Bilkey +1 more
TL;DR: Examining how prefrontal cortex lesions affected the firing of hippocampal place cells in freely moving rats suggested that place cell firing was overly influenced by local cues in the prefrontal-lesioned animals, consistent with the hypothesis that lesions of the cortex result in a disinhibition of posterior cortex.
Journal ArticleDOI
Aspartame and the hippocampus: Revealing a bi-directional, dose/time-dependent behavioural and morphological shift in mice.
TL;DR: Oral aspartame significantly altered behaviour, anti‐oxidant status and morphology of the hippocampus in mice; also, it may probably trigger hippocampal adult neurogenesis.
Iconographies supplémentaires de l'article : Combination treatment of neonatal rats with hypoxia-ischemia and endotoxin induces long-lasting memory and learning impairment that is associated with extended cerebral damage
Tomoaki Ikeda,Kenichi Mishima,Naoya Aoo,Nobuaki Egashira,Katsunori Iwasaki,Michihiro Fujiwara,Tsuyomu Ikenoue +6 more
TL;DR: Combined lipopolysaccharide and hypoxia-ischemia treatment synergistically induced short-term memory impairment that is associated with loss of cortical volume.
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Neonatal lesions of the ventral hippocampus in rats lead to prefrontal cognitive deficits at two maturational stages.
TL;DR: Premature cognitive impairments could not be predicted on the basis of the neurodevelopmental animal model of schizophrenia, Nevertheless, they appear consistent with accounts of premorbidly compromised memory, both immediate and delayed, in subgroups of schizophrenia patients.
Journal ArticleDOI
The hippocampus and prefrontal cortex are differentially involved in serial memory retrieval in non-stress and stress conditions.
Frédéric Chauveau,Christophe Piérard,Christophe Tronche,M. Coutan,Isabelle Drouet,Pierrette Liscia,Daniel Béracochéa +6 more
TL;DR: Overall, this study shows that in non-stress condition, the emergence of D1 is HPC-dependent; in stress condition, it requires the PFC integrity; moreover, intrahippocampal corticosterone injection mimicked the effects of stress in the CSD task.
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