Time-dependent relationship between the dorsal hippocampus and the prefrontal cortex in spatial memory.
Inah Lee,Raymond P. Kesner +1 more
TLDR
It is reported that the dorsal hippocampus and the medial prefrontal cortex process short-term spatial memory in parallel, serving as a compensatory mechanism for each other, indicating that the time window of memory is a key factor in dissociating multiple memory systems.Abstract:
The prefrontal cortex and the dorsal hippocampus have been studied extensively for their significant roles in spatial working memory. A possible time-dependent functional relationship between the prefrontal cortex and the dorsal hippocampus in spatial working memory was tested. A combined lesion and pharmacological inactivation technique targeting both the dorsal hippocampus and the medial prefrontal cortex was used (i.e., axon-sparing lesions of the dorsal hippocampus combined with reversible inactivation of the medial prefrontal cortex, or vice versa, within a subject). A delayed nonmatching-to-place task on a radial eight-arm maze with short-term (i.e., 10 sec) versus intermediate-term (i.e., 5 min) delays was used as a behavioral paradigm. Here we report that the dorsal hippocampus and the medial prefrontal cortex process short-term spatial memory in parallel, serving as a compensatory mechanism for each other. The role of the dorsal hippocampus, however, becomes highlighted as the time-window for memory (i.e., delay) shifts from short-term to a delay period (i.e., intermediate-term) exceeding the short-term range. The results indicate that the time window of memory is a key factor in dissociating multiple memory systems.read more
Citations
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Journal ArticleDOI
Structural and functional organization of the midline and intralaminar nuclei of the thalamus
TL;DR: While each of the midline and intralaminar nuclei are anatomically and functionally distinct, they collectively serve a vital role in several affective, cognitive and executive behaviors – as major components of a brainstem-diencephalic-thalamocortical circuitry.
Dissertation
An Examination of Hippocampal and Prefrontal Contributions to Spatial Learning and Memory using Immediate Early Gene Imaging
TL;DR: An in-depth investigation into the use of navigation strategies during memory encoding and retrieval in the water maze and to characterise the specific contributions of the hippocampus and medial prefrontal cortex to these processes using Immediate Early Genes (IEG) imaging are conducted.
Journal ArticleDOI
The dorsal hippocampus is required for the formation of long-term duration memories in rats.
TL;DR: In this paper, the authors adapted the "time-shift paradigm" to a peak-interval procedure and found that the dorsal hippocampus is required for the formation of long-term duration memories within the range of interval timing.
Journal ArticleDOI
Effects of HIV gp120 on Neuroinflammation in Immunodeficient vs. Immunocompetent States
Taxiarhia J. Arabatzis,Alexa A. Wakley,Virginia D. McLane,Virginia D. McLane,Virginia D. McLane,Dalton Canonico,Ling Cao,Ling Cao +7 more
TL;DR: Gp120 expression reduced hippocampal synaptophysin expression but did not affect animals’ learning/memory on the spontaneous T-maze test in the authors' experimental conditions, emphasizing the critical role of the neuroinflammatory micro-environment and the peripheral immune system context in which gp120 acts.
Book ChapterDOI
Chapter 8 – Neurobiological views of memory
TL;DR: In this paper, the structural and process components of memory systems at the psychological and neurobiological levels are analyzed at different levels of memory, and the authors propose a tripartite attribute-based theoretical model of memory.
References
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