Journal ArticleDOI
Aspartame and the hippocampus: Revealing a bi-directional, dose/time-dependent behavioural and morphological shift in mice.
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TLDR
Oral aspartame significantly altered behaviour, anti‐oxidant status and morphology of the hippocampus in mice; also, it may probably trigger hippocampal adult neurogenesis.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2017-03-01. It has received 32 citations till now. The article focuses on the topics: Dentate gyrus & Aspartame.read more
Citations
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Food additives, food and the concept of ‘food addiction’: Is stimulation of the brain reward circuit by food sufficient to trigger addiction?
TL;DR: There isn't sufficient scientific evidence to consider any food ingredient, micronutrient or standard food-additive as addictive, so the factors which may predispose to food addiction are discussed.
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Melatonin attenuates behavioural deficits and reduces brain oxidative stress in a rodent model of schizophrenia.
TL;DR: Melatonin may have the potential of a possible therapeutic agent and/or adjunct in the management of schizophrenia and was associated with variable degrees of reversal of these effects.
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Cyclophosphamide-induced male subfertility in mice: An assessment of the potential benefits of Maca supplement.
TL;DR: This study shows that Maca is beneficial in the mitigation of CYP‐induced male gonadal insufficiency and/or testicular morphological changes; however, further studies will be needed to ascertain its usability for this purpose in humans.
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Silymarin attenuates aspartame-induced variation in mouse behaviour, cerebrocortical morphology and oxidative stress markers
TL;DR: The study shows that co-administration of silymarin with aspartame was associated with significant attenuation of central effects, when compared to administration of aspartam alone.
Journal ArticleDOI
Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study
Oytun Erbaş,Mumin Alper Erdogan,Asghar Khalilnezhad,Volkan Solmaz,Fulya Tuzcu Gürkan,Gurkan Yigitturk,Hüseyin Avni Eroğlu,Dilek Taskiran +7 more
TL;DR: The findings suggest that long‐term consumption of artificial sweeteners may have harmful effects on cognition and hippocampal integrity in rats, and chronic intake of sweeteners significantly impaired PAL performance in all groups.
References
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New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
TL;DR: Recent progress in the integration of adult-born neurons into the circuitry of the adult hippocampus suggests an important role for adult hippocampal neurogenesis in learning and memory, but its specific function in these processes has remained elusive.
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Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain
TL;DR: The results suggest that chains of migrating neuroblasts in the SVZ may be derived from Type C cells, which had immature ultrastructural characteristics and were nestin-positive but negative to the other markers.
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A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Claire D. Clelland,Minee L. Choi,Carola Romberg,Gregory D. Clemenson,Alexandra M. C. Fragniere,P. Tyers,Sebastian Jessberger,Lisa M. Saksida,Roger A. Barker,Fred H. Gage,Timothy J. Bussey +10 more
TL;DR: Using adult mice in which hippocampal neurogenesis was ablated, this work found specific impairments in spatial discrimination with two behavioral assays: a spatial navigation radial arm maze task and a spatial, but non-navigable, task in the mouse touch screen.
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Memory, navigation and theta rhythm in the hippocampal-entorhinal system
György Buzsáki,Edvard I. Moser +1 more
TL;DR: It is proposed that mechanisms of memory and planning have evolved from mechanisms of navigation in the physical world and hypothesize that the neuronal algorithms underlying navigation in real and mental space are fundamentally the same.
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Regional dissociations within the hippocampus--memory and anxiety.
David M. Bannerman,J. N. P. Rawlins,Stephen B. McHugh,Robert M. J. Deacon,Benjamin K. Yee,Tobias Bast,Wei-Ning Zhang,Helen H. J. Pothuizen,Joram Feldon +8 more
TL;DR: Gray and McNaughton's theory can in principle incorporate these apparently distinct hippocampal functions, and provides a plausible unitary account for the multiple facets of hippocampal function.