Journal ArticleDOI
To investigate the role of Withania somnifera in a mouse model of posttraumatic stress disorder
Ravjot Kaur,Amteshwar Singh Jaggi,Anjana Bali +2 more
- Vol. 3, Iss: 4, pp 153
TLDR
It is concluded that W. somnifera may be beneficial in preventing the PTSD symptoms in response to a traumatic event and considerably restored the behavioral changes and normalized the corticosterone levels.Abstract:
The present study was conducted to explore the role of Withania somnifera in posttraumatic stress disorder (PTSD) in mice. Swiss albino mice were subjected to a 2-day electric foot-shock stress of 5 min, which included 15 alternating inescapable foot shocks of 0.8 mA intensity with 10-s duration and 10-s intershock interval on the electrified grid floor. It was followed by 3 week re-exposures (on day 3, 7, and 14) in the same context (as situational reminders) for 5 min without delivering any foot-shocks. Trauma and situational reminders results a significant development of behavioral deficits and reduced serum corticosterone levels, as assessed on the 21st day. A significant development of freezing behavior was also observed in response to situational reminders on 3rd, 7th and 14th days. Repeated administration (for 21 days) of W. somnifera (50 mg/kg and 100 mg/kg) considerably restored the behavioral changes and normalized the corticosterone levels. W. somnifera led to significant reduction in the freezing behavior in response to situational reminders suggesting the inhibition of formation of aversive fear memory. It may be concluded that W. somnifera may be beneficial in preventing the PTSD symptoms in response to a traumatic event.read more
Citations
More filters
Journal ArticleDOI
Synergistic effects of combined therapy with cerebrolysin and enriched environment on anxiety-like behavior and spatial cognitive deficits in posttraumatic stress disorder-like mouse model
TL;DR: In this article , the authors evaluated the possible therapeutic effects of enriched environment (EE) and Cerebrolysin (CBL) alone or combined for reducing anxiety and cognitive deficits in PTSD-like mouse models.
Journal ArticleDOI
Synergistic effects of combined therapy with cerebrolysin and enriched environment on anxiety-like behavior and spatial cognitive deficits in posttraumatic stress disorder-like mouse model
Leila Hosseini,Saeed Sadigh-Eteghad,Fereshteh Farajdokht,Hanieh Salehi-Pourmehr,Amir Pasokh,Mojtaba Ziaee,Siamak Sandoghchian Shotorbani,Mir-Jamal Hosseini,Javad Mahmoudi +8 more
TL;DR: In this article , the authors evaluated the possible therapeutic effects of enriched environment (EE) and Cerebrolysin (CBL) alone or combined for reducing anxiety and cognitive deficits in PTSD-like mouse models.
References
More filters
Journal ArticleDOI
Posttraumatic stress disorder in the National Comorbidity Survey.
TL;DR: Progress in estimating age-at-onset distributions, cohort effects, and the conditional probabilities of PTSD from different types of trauma will require future epidemiologic studies to assess PTSD for all lifetime traumas rather than for only a small number of retrospectively reported "most serious" traumAs.
Journal ArticleDOI
Empathy and Pro-Social Behavior in Rats
TL;DR: Rats behave pro-socially in response to a conspecific’s distress, providing strong evidence for biological roots of empathically motivated helping behavior.
Journal ArticleDOI
Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration.
TL;DR: Using a battery of behavioral tests after termination of the stress procedure, it is found that anhedonia, but not chronic stress per se, is associated with key analogues of depressive symptoms, such as increased floating during forced swimming and decreased exploration of novelty.
Journal ArticleDOI
An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda.
TL;DR: Withania somnifera (WS) is an anti-inflammatory and anti-arthritic agent and was found useful in clinical cases of Rheumatoid and Osteoarthritis and neurodegenerative diseases such as Parkinson's, Huntington's and Alzeimer's diseases.