Showing papers in "Phytomedicine in 2014"

TL;DR: In this article, the authors evaluated both the antioxidant and intestinal anti-inflammatory activities of six coumarin derivatives of plant origin (scopoletin, scoparone, fraxetin, 4-methyl-umbeliferone, esculin and daphnetin) to verify if potential intestinal anti inflammatory activity was related to antioxidant properties.

TL;DR: Findings show that coumarins have potential use in antivirulence strategies against persistent E. coli O157:H7 infection and are in-line with observed reductions in fimbriae production, swarming motility, and biofilm formation.

TL;DR: An attempt has been made to explore traditional uses and pharmacological properties of A. calamus to explore its therapeutic potentials and its uses are yet to be scientifically validated.

TL;DR: The isolate which was identified as member of Colletotrichum gloeosporioides was found to have the ability to form piperine and was confirmed by HPLC and LCMS.

TL;DR: This article focuses on the occurrence and biological activities of cyclobutane-containing (CBC) alkaloid obtained from fungi, fungal endophytes, and plants and presents the structures and describes the activities of 98 CBC alkaloids.

TL;DR: The abilities to inhibit proinflammatory cytokines and modulation of antioxidant status suggest that the protective effect of Boswellia serrata extract on arthritis in rats might be mediated via the modulation of immune system.

TL;DR: The structure-activity relationship indicated that the presence of ether and ester groups in ISL and LTG analogues are important for exhibiting the activity, and is the first report on antidiabetic activity of ISL derivative 4 andLTG derivative 10.

TL;DR: The results suggest that tetrandrine and fangchinoline can reverse MDR by increasing the intracellular concentration of anticancer drugs, and thus they could serve as a lead for developing new drugs to overcome P-gp mediated drug resistance in clinic cancer therapy.

TL;DR: It is concluded that daily intake of 5ml N. sativa oil for two months improves abnormal semen quality in infertile men without any adverse effects.

TL;DR: It is demonstrated that trans-caryophyllene reduced both acute and chronic pain in mice, which may be mediated through the opioid and endocannabinoid systems.

TL;DR: Results show that tangeretin modulates the activities of hepatic enzymes via enhanced secretion of insulin and decreases the blood glucose in streptozotocin induced diabetic rats by its antioxidant potential.

TL;DR: The cytotoxicity of the studied xanthones and especially compound 3 deserve more detailed exploration in the future to develop novel anticancer drugs against sensitive and otherwise drug-resistant phenotypes.

TL;DR: Investigation of the reversal of P-gp mediated multidrug resistance in colon cancer cells by five tanshinones suggests that cryptotanshinone and dihydrotanshin one could be further developed for sensitizing resistant cancer cells and used as an adjuvant therapy together with anticancer drugs to improve their therapeutic efficacies for colon cancer.

TL;DR: The data obtained from the present study strongly indicate that diosgenin has potential effects on cardiovascular risk, insulin secretion and beta cell regeneration in STZ induced diabetic rats, these results could be useful for new drug development to fight diabetes and its related cardiovascular diseases.

TL;DR: The study concluded that CFDL, DS and HDS have marked anti-nociceptive, anti-inflammatory and sedative effect and strongly supports the ethno-pharmacological uses of D. lotus as anti-magnifying and anti-inflammation as well as sedative in open field animal models.

TL;DR: CBD BDS attenuates colon carcinogenesis and inhibits colorectal cancer cell proliferation via CB1 and CB2 receptor activation.

TL;DR: The inhibitory ability of DSF-52 on microglia- mediated neuroinflammation may offer a novel neuroprotective modality and could be potentially useful in inflammation-mediated neurodegenerative diseases.

TL;DR: Results lead to a hypothesis that prenyl group might be crucial to exhibit the activity of osteoblasts proliferation and differentiation activity in mouse primary calvarial osteoblASTs.

TL;DR: Ginsenoside Rg1 as a ginsenosideside neuroprotective agent could improve neurological injury, attenuate blood brain barrier disruption and downregulate aquaporin 4 expression induced by cerebral ischemia/reperfusion insults in rats.

TL;DR: The observed synergy and mechanism of action between phytochemicals and synthetic drugs in effectively combating differs significantly than that of the drugs alone; hence isolating a single component may lose its importance thereby simplifying the task of pharma industries.

TL;DR: It is remarkable that the combinations could enhance the sensitivity of E. coli to vancomycin 16-fold to which it is normally insensitive, and provided proof for the concept, that combinations of known antibiotics with modern phytotherapeutics can expand the spectrum of useful therapeutics.

TL;DR: In vitro experiments to investigate the inhibitory activity of diosgenin on human breast cancer MDA-MB-231 cell migration, and reveal the possible mechanism, reveal a new therapeutic potential of diOSgenin for human breast cancers metastasis therapy.

TL;DR: Evidence is provided that an aqueous extract of fermented rooibos protects cardiomyocytes, derived from diabetic rats, against experimentally induced oxidative stress and ischemia and was better than the known antioxidant vitamin E.

TL;DR: It is proven that the cornelian cherry could have protective effects on diet-induced hypertriglicerydemia and atherosclerosis through enhanced PPARα protein expression and via regulating oxidative stress and inflammation.

TL;DR: Results demonstrate for the first time that LPNS has antioxidative effects which may be neuroprotective in neurological disorders.

TL;DR: The development and characterization of self-nanoemulsifying drug delivery system (SNEDDS) of berberine in liquid as well as solid form with improved solubility, dissolution and in vivo therapeutic efficacy are described.

TL;DR: It is indicated that asiatic acid showed an antihyperlipidemic effect in addition to its antidiabetic effect in experimental diabetes.

TL;DR: The production of rohitukine and its subsequent attenuation by endophytic fungi is reported and the mechanism by which the fungi produce the host metabolite in culture is unraveled.

TL;DR: It was found that transgelin 2 may mediate the resistance of MCF-7/PTX cells to paclitaxel by up-regulating the expressions of the adenosine-triphosphate binding cassette transporter proteins, including P-glycoprotein (P-gp), multidrug resistance associated protein 1 (MRP1), and breast cancer resistance protein (BCRP).

TL;DR: It is demonstrated that EDNLA attenuates L PS-induced hyperphosphorylation of tau protein in rat's hippocampus and protects against LPS-induced apoptosis in rat brain.