Track structure and the calculation of biological effects of heavy charged particles.
M. Scholz,G. Kraft +1 more
TLDR
A new approach for the calculation of biological effects of heavy charged particles is discussed, in contrast to other models, the biological effect is determined locally as a function of the local dose deposited by the charged particle tracks.About:
This article is published in Advances in Space Research.The article was published on 1996-01-01 and is currently open access. It has received 254 citations till now. The article focuses on the topics: Charged particle & Charged particle beam.read more
Citations
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Heavy-ion tumor therapy: Physical and radiobiological benefits
TL;DR: Results of clinical phase I-II trials provide evidence that carbon-ion radiotherapy might be beneficial in several tumor entities, and the progress in heavy-ion therapy is reviewed, including physical and technical developments, radiobiological studiesmore and models, as well as radiooncological studies.
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Treatment planning for heavy-ion radiotherapy: calculation and optimization of biologically effective dose.
TL;DR: A novel approach to treatment planning for heavy-ion radiotherapy based on the local effect model (LEM) which allows us to calculate the biologically effective dose not only for the target region but also for the entire irradiation volume.
Journal ArticleDOI
Computation of cell survival in heavy ion beams for therapy. The model and its approximation
TL;DR: A simplified method for the calculation of mammalian cell survival after charged particle irradiation is presented that is based on the track structure model of Scholz and Kraft, and yields linear-quadratic relations also for heavy ion irradiation.
Journal ArticleDOI
Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model.
Taku Inaniwa,Takuji Furukawa,Yuki Kase,Naruhiro Matsufuji,Toshiyuki Toshito,Yoshitaka Matsumoto,Yoshiya Furusawa,Koji Noda +7 more
TL;DR: Good agreement between the two curves proves that the proposed method is a candidate for calculating the biological effects in treatment planning for ion irradiation.
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Accuracy of the local effect model for the prediction of biologic effects of carbon ion beams in vitro and in vivo.
TL;DR: The modified track structure description represents an empiric approach to improve the accuracy of the LEM for treatment planning and will be particularly useful for further optimization of carbon ion therapy in general and with respect to comparison with other treatment modalities.
References
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Range and stopping-power tables for heavy ions
L.C. Northcliffe,R.F. Schilling +1 more
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Theory of RBE for heavy ion bombardment of dry enzymes and viruses.
J. J. Butts,Robert Katz +1 more
TL;DR: The response of dry enzymes and viruses to heavy ion bombardment may be predicted from their response to γ-irradiation (and no further knowledge of their size and structure).
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Inactivation of cells by heavy ion bombardment.
TL;DR: The tracks formed in nuclear emulsion by energetic heavy ions are made up of grains sensitized by the passage of a single ion.
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Range and stopping-power tables for 2.5–500 MeV/nucleon heavy ions in solids
F. Hubert,R. Bimbot,H. Gauvin +2 more
TL;DR: In this article, stopping powers and ranges for all ions of atomic number 2 ≤ Z ≤ 103 in the energy region 2.5 ≤ E A ≤ 500 MeV/u for 36 solid materials were tabulated.
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Mutation and inactivation of cultured mammalian cells exposed to beams of accelerated heavy ions. II. Chinese hamster V79 cells.
TL;DR: It is suggested that a proportion of the radiation-induced mutants suffer extensive genetic damage, and that some forms of this damage may be induced with high efficiency by radiations of high linear energy transfer.