Twenty-year trends in prevalence and survival of Down syndrome
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One-year survival of live births with Down syndrome increased, especially in babies with cardiovascular malformations, reaching almost 100%, and there has been no overall change in live birth prevalence.Abstract:
The aims of this study were (1) to determine trends in total prevalence and live birth prevalence of Down syndrome, (2) to analyse trends in factors likely to influence this prevalence and (3) to determine 1-year survival in Down syndrome A retrospective review was made of prospectively collected data on all cases of Down syndrome within a malformation registry born in 1985-2004 Down syndrome affected 1188 pregnancies among 690 215 live births (172 per 1000 total births) The proportion increased over 20 years from 13 to 25 per 1000 total births (P<00001) There were 389 terminations for Down syndrome and 51 stillbirths There were 748 live births with Down syndrome (108 per 1000 live births) The live birth prevalence declined in 1985-1994 and increased in 1995-2004 with no overall change Total live births in the population declined by 20% over 20 years Mothers delivering at 35 years of age or above increased from 6 to 15% The uptake of maternal serum screening increased from zero in 1987 to 35% in 1993 but then plateaued One-year survival of live births with Down syndrome increased, especially in babies with cardiovascular malformations, reaching almost 100% The prevalence of pregnancies affected by Down syndrome has increased significantly, but there has been no overall change in live birth prevalence Increasing maternal age and improved survival of children with Down syndrome have offset the effects of prenatal diagnosis followed by the termination of pregnancy and declining general birth rateread more
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Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe: impact of maternal age and prenatal screening
Maria Loane,Joan K. Morris,Marie-Claude Addor,Larraitz Arriola,Judith L. S. Budd,Bérénice Doray,Ester Garne,Miriam Gatt,Martin Haeusler,Babak Khoshnood,Kari Klungsøyr Melve,Anna Latos-Bielenska,Bob McDonnell,Carmel Mullaney,Mary O'Mahony,Annette Queißer-Wahrendorf,Judith Rankin,Anke Rissmann,Catherine Rounding,Joaquin Salvador,David Tucker,Diana Wellesley,Lyubov Yevtushok,Helen Dolk +23 more
TL;DR: There was an increase in total and total corrected prevalence of all three trisomies over time, mainly explained by increasing maternal age and the rise in maternal age, and live birth prevalence has remained stable overall.
Journal ArticleDOI
Clinical practice: The care of children with Down syndrome
TL;DR: An overview of the most important issues related to children with DS based on the most relevant literature currently available is presented.
Journal ArticleDOI
Prevalence of Down Syndrome Among Children and Adolescents in 10 Regions of the United States
Mikyong Shin,Mikyong Shin,Lilah M. Besser,James E. Kucik,Chengxing Lu,Chengxing Lu,Csaba Siffel,Csaba Siffel,Adolfo Correa +8 more
TL;DR: Prevalence estimates of Down syndrome among children and adolescents from 10 US regions varied according to region, race/ethnicity, and gender, suggesting possible variation in prevalence at birth or in survival rates on the basis of these characteristics.
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Atypical aging in Down syndrome.
TL;DR: This chapter is divided into two sections: the first section will review typical and atypical aging patterns in somatic issues in elder adults with DS and the multifaceted relationship between AD and DS.
Journal ArticleDOI
Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome
TL;DR: Results suggest that the application of SOM to new experimental data sets of complex protein profiles can be used to identify common critical protein responses, which in turn may aid in identifying potentially more effective drug targets.
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Health care management of adults with Down syndrome.
TL;DR: Because of improvements in health care and better education, and because more people with this condition are being raised at home, most adults with Down syndrome can expect to function well enough to live in a group home and hold a meaningful job.