Journal ArticleDOI
Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus.
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TLDR
The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins, while ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.Abstract:
The RNP and Sm antigens recognized by lupus erythematosus antibodies are located on discrete particles containing single small nuclear RNA's complexed with proteins. The antigens Ro and La are also on ribonucleoproteins. The small RNA's in ribonucleoproteins with Ro are discrete, like those associated with RNP and Sm; in contrast, ribonucleoproteins with La contain a striking highly banded spectrum of small RNA's from uninfected cells as well as virus-associated RNA from adenovirus-infected cells.read more
Citations
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Journal ArticleDOI
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.
TL;DR: Systemic lupus erythematosus is a multisystem autoimmune disease in which the autoantibody response targets a variety of autoantigens of diverse subcellular location, and it is shown that they are clustered in two distinct populations of blebs at the surface of apoptotic cells.
Book ChapterDOI
Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology
TL;DR: One of the purposes of this chapter is to show that the new molecular biology of cellular antigens and auto-antibodies could now be providing insights into comprehending some features of autoimmunity.
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Transcription termination and 3' processing: the end is in site!
TL;DR: In this article, it was shown that 3' cleavage of pre-mRNA in eukaryotes is, in many ways, the phenotypic equivalent of transcription termi-nation.
Book ChapterDOI
Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.
TL;DR: Autoantibodies to nuclear antigens (ANAs) have assumed an important place in the diagnostic armamentarium of the clinician because of distinct profiles of ANAs in different diseases.
Journal ArticleDOI
Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease
TL;DR: The monoclonal anti-Sm antibody gives the same immunoprecipitation pattern, providing direct evidence that the Sm antigen resides on all these RNA-protein complexes, which will be valuable in deciphering the biological function of these ubiquitous small nuclear RNPs.
References
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Journal ArticleDOI
Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA)
TL;DR: The detection of antibody to ENA with a well defined specificity allows recognition of an apparently distinct mixed connective tissue disease syndrome which is characterized by an excellent response to corticosteroid therapy and a favorable prognosis.
Journal ArticleDOI
Are snRNPs involved in splicing
TL;DR: Several lines of evidence are presented that suggest a direct involvement of snRNPs in the splicing of hnRNA molecules, including the observation that the nucleotide sequence at the 5′ end of U1 RNA exhibits extensive complementarity to those across splice junctions in hn RNA molecules.
Journal ArticleDOI
Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus
Michael R. Lerner,Joan A. Steitz +1 more
TL;DR: It is argued that each of the six snRNAs exists in a separate small nuclear ribonucleoprotein (snRNP) complex with a total molecular weight of about 175,000.
Journal Article
Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus
Eng M. Tan,H. G. Kunkel +1 more
TL;DR: Sera of patients with systemic lupus erythematosus were demonstrated to contain precipitating antibodies to soluble tissue components other than DNA, and one dominant reaction was observed which was provisionally termed the Sm system.
Journal Article
Characterization of a Soluble Cytoplasmic Antigen Reactive with Sera from Patients with Systemic Lupus Erythmatosus
TL;DR: A tissue antigen reactive with sera from SLE patients has been partially characterized and is an acidic macromolecule which has the electrophoretic mobility of an α 1 globulin and is resistant to most proteolytic enzymes including trypsin, pepsin and chymotrypsin.
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Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus
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