Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus.
Reads0
Chats0
TLDR
In this article, Epstein-Barr virus (EBV) encodes two small RNAs, EBER 1 and EBER 2, which are associated with protein(s) allowing their specific precipitation by the systemic lupus erythematosus-associated antibody anti-La.Abstract:
Primate cells harboring the Epstein-Barr virus (EBV) genome synthesize large amounts of two small RNAs:EBER 1 and EBER 2 (EBV-encoded RNA). These RNAs are approximately 180 nucleotides long, possess 5' pppA termini, and lack poly(A). They have different T1 and pancreatic RNase digestion fingerprints. They are not found in normal B lymphocytes, in transformed B lymphocytes that lack EBV DNA, in T lymphocytes transformed by Herpesvirus ateles, or in a variety of other nonlymphoid mammalian cells. Hybridization analyses indicate that EBER 1 and EBER 2 are encoded by the EcoRI-J fragment of EBV (B95-8) DNA. In vivo both RNAs are associated with protein(s), allowing their specific precipitation by the systemic lupus erythematosus-associated antibody anti-La. The La antigen in uninfected mammalian cells consists of a heterogeneous class of small ribonucleoprotein particles, some of whose RNA components exhibit sequence homology with a highly repetitive, interspersed class of human DNA designated the Alu family. Possible functions for EBER 1 and EBER 2 in infection and cell transformation by EBV and their potential relationship to the pathogenesis of systemic lupus erythematosus are discussed.read more
Citations
More filters
Journal ArticleDOI
RNA Polymerase III Detects Cytosolic DNA and Induces Type-I Interferons Through the RIG-I Pathway
TL;DR: It is shown that the cytosolic poly(dA-dT) DNA is converted into 5'-ppp RNA to induce IFN-beta through the RIG-I pathway, suggesting that RNA Pol-III is a cytosol DNA sensor involved in innate immune responses.
Book ChapterDOI
Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine.
TL;DR: Autoantibodies to nuclear antigens (ANAs) have assumed an important place in the diagnostic armamentarium of the clinician because of distinct profiles of ANAs in different diseases.
Journal ArticleDOI
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
Andrea Ablasser,Franz Bauernfeind,Gunther Hartmann,Eicke Latz,Katherine A. Fitzgerald,Veit Hornung +5 more
TL;DR: A novel DNA-sensing pathway involving RNA polymerase III and RIG-I is identified, which was important in the sensing of Epstein-Barr virus–encoded small RNAs, which were transcribed by RNA polymer enzyme III and then triggered Rig-I activation.
Journal ArticleDOI
Plasmablastic Lymphomas of the Oral Cavity: A New Entity Associated With the Human Immunodeficiency Virus Infection
Henri Jacques Delecluse,Ioannis Anagnostopoulos,Ioannis Anagnostopoulos,Friederike Dallenbach,Friederike Dallenbach,Michael Hummel,Michael Hummel,Teresa Marafioti,Teresa Marafioti,U. Schneider,U. Schneider,D. Huhn,D. Huhn,A. Schmidt-Westhausen,A. Schmidt-Westhausen,Peter A. Reichart,Peter A. Reichart,Ulrich Gross,Ulrich Gross,Harald Stein,Harald Stein +20 more
TL;DR: A series of 16 highly malignant diffuse large B-cell lymphomas of the oral cavity with unique immunohistologic features that developed in human immunodeficiency virus-positive patients are reported, and it is proposed to name these tumors plasmablastic lymphomas, in accordance with their morphologic and immunohISTologic features.
Journal ArticleDOI
Epstein-Barr virus and oncogenesis: from latent genes to tumours.
Lawrence S. Young,Paul Murray +1 more
TL;DR: This review summarises the current knowledge of EBV latent gene function and how this relates to the role of the virus in the aetiology of different tumours.
References
More filters
Journal ArticleDOI
Oncogenesis and Herpesviruses
TL;DR: This is the second of a series of volumes on different aspects of cancer prepared under the auspices of the International Agency for Research on Cancer; they soon become recognized as useful additions to the list of publications on cancer.
Related Papers (5)
Localization of Epstein-Barr virus-encoded small RNAs by in situ hybridization.
J G Howe,Joan A. Steitz +1 more