Journal ArticleDOI
Ultrastructural Changes in the Spermatozoa of Langur Monkeys Presbytis entellus entellus After Vas Occlusion With Styrene Maleic Anhydride
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TLDR
The results indicate that the necrospermic status of the spermatozoa during initial ejaculations may offer instant sterility after vas occlusion with SMA.About:
This article is published in Contraception.The article was published on 1998-02-01. It has received 26 citations till now. The article focuses on the topics: Vas deferens.read more
Citations
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Journal ArticleDOI
Sperm pathology: a step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile men
Héctor E. Chemes,Vanesa Y. Rawe +1 more
TL;DR: Sperm pathology is presented as the discipline of characterizing structural and functional deficiencies in abnormal spermatozoa, providing correlations of prognostic value with sperm fertilizing capacity, explaining the mechanisms of sperm inefficiency, suggesting strategies to improve fertilization and opening a door to molecular genetic studies.
Journal ArticleDOI
New frontiers in nonhormonal male contraception.
C. Yan Cheng,Dolores D. Mruk +1 more
TL;DR: Several approaches for fertility control involving the testis that one day may lead to the development of a nonhormonal male contraceptive are discussed.
Journal ArticleDOI
Intravasal contraception with styrene maleic anhydride and its noninvasive reversal in langur monkeys (Presbytis entellus entellus)
TL;DR: The results suggest that noninvasive reversal technique offers the possibility of the functional azoospermia reversal within a short period of time.
Journal Article
Vas deferens a site of male contraception: an overview.
TL;DR: RISUG, a non-sclerotic polymer styrene maleic anhydride (SMA), could be more advantageous than vasectomy and other vas occlusive procedures in that it could be a totally non-invasive procedure by "no-scalpel injection and "non- invasive reversal".
Journal ArticleDOI
Status of Spermatogenesis and Sperm Parameters in Langur Monkeys Following Long‐term Vas Occlusion With Styrene Maleic Anhydride
Pradyumna Kumar Mishra,B. Manivannan,Neelam Pathak,S. Sriram,Satish S. Bhande,S. Panneerdoss,Nirmal K. Lohiya +6 more
TL;DR: The results suggest focal degeneration of seminiferous epithelium in the central portion of the testis following long-term vas occlusion with SMA.
References
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Journal ArticleDOI
Phase II clinical trial of a vas deferens injectable contraceptive for the male
Sujoy K. Guha,Sujoy K. Guha,Gulshanjit Singh,Shirfuddin Ansari,Sudheer Kumar,Anil K. Srivastava,Veena Koul,H.C. Das,Rishi Malhotra,Subhadeep Das +9 more
TL;DR: The results reconfirm the safety and show that for a period of at least 1 year, the treatment leads to azoospermia in the male and gives pregnancy protection.
Journal ArticleDOI
Phase I clinical trial of an injectable contraceptive for the male.
TL;DR: A Phase I clinical trial was undertaken on 38 male volunteers giving varying doses of SMA, ranging between 5 mg and 140 mg, into each vas deferens, finding the treatment is well tolerated with only minimal side effects in a few cases and no long-term adverse effects.
Patent
Contraceptive for use by a male
TL;DR: In this article, the contraceptive consists of a copolymer of styrene maleic anhydride which is prepared by the step of irradiation at a dose of 0.2 to 0.24 megarad for every 40 gms.
Journal ArticleDOI
Contraception in male monkeys by intra-vas deferens injection of a pH lowering polymer
TL;DR: A new male method of contraception by injecting a polymer, styrene-maleic anhydride (SMA), into the lumen of the vas deferens has been studied on rhesus monkeys, indicating that the contraceptive effect will last for a considerably long period.
Journal ArticleDOI
Chronic toxicity of styrene maleic anhydride, a male contraceptive, in rhesus monkeys ( Macaca mulatta )
TL;DR: The results suggest the polymer SMA to be safe up to 5 times CD in monkeys.