Unanticipated signaling events associated with cardiac adenylyl cyclase gene transfer
Mei Hua Gao,H. Kirk Hammond +1 more
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TLDR
The published papers on the effects of increased cardiac expression of adenylyl cyclase type 6 (AC6) are reviewed and the effects in cultured neonatal and adult rat cardiac myocytes are discussed in the context of attempting to establish mechanisms for the unanticipated beneficial effects of AC6 on the failing heart.About:
This article is published in Journal of Molecular and Cellular Cardiology.The article was published on 2011-05-01 and is currently open access. It has received 13 citations till now. The article focuses on the topics: Adenylyl cyclase.read more
Citations
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Cardiovascular gene therapy for myocardial infarction
TL;DR: This review will focus on elucidating current molecular targets for the treatment of ventricular dysfunction following myocardial infarction (MI), the clinical consequences of it, and the 4 prerequisites of success of any gene target therapy: safety, expression, specificity and efficacy.
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Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma
Fiona Murray,Paul A. Insel +1 more
TL;DR: This ‘pathway approach' targeted to cAMP has identified GPCR agonists/antagonists, ACactivators, AC activators, PDE inhibitors and/or activators or inhibitors of downstream mediators (PKA and Epac, respectively), which might be utilized therapeutically in CLL.
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Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function
Toshio Nagai,Issei Komuro +1 more
TL;DR: Although further research is needed in both preclinical and clinical areas in terms of molecular mechanisms, safety, and efficiency, both gene and cytokine therapy have a great possibility to open the new era of the treatment of HF.
Identification of novel drug targets for the treatment of heart failure
TL;DR: It is indicated that myocardial BNP gene delivery can achieve pleiotropic, context-dependent, favourable effects on cardiac function and that BNP can act locally as a mechanical load–activated regulator of angiogenesis and fibrosis.
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Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms.
TL;DR: An AC2 cAMP signaling compartment is defined that specifically regulates IL-6 expression in BSMC via Epac and PKA and demonstrates that other AC isoforms are excluded from this pool.
References
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Lipid rafts bringing order to chaos
TL;DR: The role of lipid rafts in signaling via receptor tyrosine kinases and G protein-coupled receptors is summarized and studies that have helped to elucidate the role are summarized.
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Complexity and Diversity of Mammalian Adenylyl Cyclases
TL;DR: The discovery of new isoforms of mammalian adenylyl cyclase has revealed unanticipated mechanisms of regulation, including activation or inhibition by the G-protein beta gamma subunit complex, inhibition by G(o) alpha, inhibited by Ca2+, and phosphorylation by protein kinases C and A.
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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.
TL;DR: It is concluded that overexpression of beta1-adrenergic receptors in the heart may lead to a short-lived improvement of cardiac function, but that increasedbeta1- adrenergic receptor signalling is ultimately detrimental.
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The fine structure of the gall bladder epithelium of the mouse
TL;DR: Sections of mouse gall bladder epithelium fixed by perfusion with buffered osmium tetroxide have been studied in the electron microscope as an example of simple columnar epithelio, which is largely a cytoplasmic and cell membrane structure, rather than being primarily intercellular in nature.
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Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with Gsα·GTPγS
TL;DR: The crystal structure of a catalytically active form of adenylyl cyclase in a complex with its stimulatory heterotrimeric G protein α subunit (Gs α) and forskolin was determined to a resolution of 2.3 angstroms as discussed by the authors.