Ursolic acid a promising candidate in the therapeutics of breast cancer: Current status and future implications.
Javed Iqbal,Banzeer Ahsan Abbasi,Riaz Ahmad,Tariq Mahmood,Sobia Kanwal,Barkat Ali,Ali Talha Khalil,Sayed Afzal Shah,Muhammad Maqsood Alam,Hussain Badshah +9 more
TLDR
Ursolic acid is widely spread in fruits and vegetables having the ability to inhibit BC proliferation, angiogenesis and metastasis, arrest cell cycle, induced apoptosis, scavenge free radicals and regulate several anti-apoptotic and pro-APoptotic proteins.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2018-09-21 and is currently open access. It has received 77 citations till now. The article focuses on the topics: Cancer & Hormonal therapy.read more
Citations
More filters
Journal ArticleDOI
Green synthesis and characterizations of Nickel oxide nanoparticles using leaf extract of Rhamnus virgata and their potential biological applications
Journal ArticleDOI
Plant-extract mediated green approach for the synthesis of ZnONPs: Characterization and evaluation of cytotoxic, antimicrobial and antioxidant potentials
TL;DR: ZnONPs have shown potential biological applications and should be subjected to further in vivo studies on toxicity in animal models to develop its nano-pharmacological relevance in biomedical applications.
Journal ArticleDOI
Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression.
TL;DR: The antioxidant and anti-inflammatory axis of UA's pharmacology is appraised for its therapeutic potential in some common CNS disorders.
Journal ArticleDOI
Potential phytochemicals in the fight against skin cancer: Current landscape and future perspectives.
Javed Iqbal,Banzeer Ahsan Abbasi,Riaz Ahmad,Riffat Batool,Tariq Mahmood,Barkat Ali,Barkat Ali,Ali Talha Khalil,Ali Talha Khalil,Ali Talha Khalil,Sobia Kanwal,Sayed Afzal Shah,Muhammad Maqsood Alam,Muhammad Maqsood Alam,Sheeza Bashir,Hussain Badshah,Hussain Badshah,Akhtar Munir +17 more
TL;DR: In this article, a review of the key phytochemicals, their therapeutic potentials, bioavailability and molecular mechanism of action in the cancer therapeutics are discussed, current challenges and future directions for research are also critically discussed.
Journal ArticleDOI
Bioactivities of Geranium wallichianum Leaf Extracts Conjugated with Zinc Oxide Nanoparticles.
Banzeer Ahsan Abbasi,Javed Iqbal,Riaz Ahmad,Layiq Zia,Sobia Kanwal,Tariq Mahmood,Canran Wang,Jen-Tsung Chen +7 more
TL;DR: Bioactivities of GW-ZnONPs including antimicrobial potentials, cytotoxicity, antioxidative capacities, inhibition potentials against α-amylase, and protein kinases, as well as biocompatibility were intensively tested and confirmed.
References
More filters
Journal ArticleDOI
Cancer statistics, 2018
TL;DR: The combined cancer death rate dropped continuously from 1991 to 2015 by a total of 26%, translating to approximately 2,378,600 fewer cancer deaths than would have been expected if death rates had remained at their peak.
Journal ArticleDOI
Cancer statistics, 2017
TL;DR: The American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival.
PatentDOI
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
TL;DR: In this paper, the rictor-mTOR complex was used to identify compounds which modulate Akt activity mediated by the Rictor mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activation.
Journal ArticleDOI
Breast cancer statistics, 2013
TL;DR: An overview of female breast cancer statistics in the United States, including data on incidence, mortality, survival, and screening is provided, with African American women having the poorest breast cancer survival of any racial/ethnic group.
Journal ArticleDOI
Biological subtypes of breast cancer: Prognostic and therapeutic implications.
Özlem Yersal,Sabri Barutca +1 more
TL;DR: Gene signatures have been developed as predictors of response to therapy and protein gene products that have direct roles in driving the biology and clinical behavior of cancer cells are potential targets for the development of novel therapeutics.