Use of hydrophilic contact lenses to increase ocular penetration of topical drugs.

TLDR: Bionite lenses, either untreated or pretreated with fluorescein, markedly increase the concentration of this drug in the anterior segment of the eye, suggesting that these lenses may be useful adjuncts in attaining and maintaining high drug concentrations in the eye without the use of frequent topical medication.

Abstract: Hydrophilic contact lenses take up and release fluorescein from solution in a measurable manner. This is more rapid with Bionite than with the Soflens lenses. Bionite lenses, either untreated or pretreated with fluorescein, markedly increase the concentration of this drug in the anterior segment of the eye. This suggests that these lenses may be useful adjuncts in attaining and maintaining high drug concentrations in the eye without the use of frequent topical medication. The drug concentration attained with these lenses is higher than that possible with frequent topical medication alone.