Validação de métodos analíticos: estratégia e discussão
Natilene Mesquita Brito,Ozelito Possidônio de Amarante Junior,Luciana Polese,Maria Lúcia Ribeiro +3 more
- Vol. 13, Iss: 13, pp 129-146
TLDR
In this paper, the authors present the definitions of the parameters (selectivity, limits of detection and quantification, accuracy, precision,linearity, analytical graphic, sensitivity and ruggedness) considered on analytical methods validation procedures.Abstract:
Neste trabalho sao apresentadas as definicoes dos
parâmetros (seletividade, limites de deteccao e
quantificacao, exatidao, precisao, linearidade, grafico
analitico, sensibilidade e robustez) considerados nos
processos de validacao de metodos analiticos. A
estrategia a ser adotada para a determinacao desses
parâmetros depende do proposito e da natureza do
metodo. Exemplos sao apresentados para a
avaliacao dos parâmetros no procedimento de
validacao.
ANALYTICAL METHODS VALIDATION: STRATEGY AND DISCUSSION
Abstract
This paper presents the definitions of the parameters (selectivity, limits of detection and quantification, accuracy, precision,
linearity, analytical graphic, sensitivity and ruggedness) considered on analytical methods validation procedures. The strategy to be adopted for determinations of these parameters depends on the purpose and the nature of the method.
Some examples are presented for parameters evaluation in a validation procedure.read more
Citations
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A digital image method of spot tests for determination of copper in sugar cane spirits
Kenia Dias Pessoa,Willian Toito Suarez,Marina Ferreira dos Reis,Mathews de Oliveira Krambeck Franco,Renata Pereira Lopes Moreira,Vagner Bezerra dos Santos +5 more
TL;DR: The spot test method associated with DIB allows the use of devices as digital cameras and smartphones to evaluate colorimetric reaction with low waste generation, practicality, quickness, accuracy, precision, high portability and low-cost.
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Determination of ethyl carbamate in cachaça produced from copper stills by HPLC
Ana Maria de Resende Machado,M. das G. Cardoso,Adelir Aparecida Saczk,Jeancarlo Pereira dos Anjos,Lidiany Mendonça Zacaroni,Haroldo Silveira Dórea,David Lee Nelson +6 more
TL;DR: The results show that the analytical method is accurate, reproducible and linear over the concentration range from 5.0 to 160 μg of EC per litre, and was applied to the analysis of EC in cachaça, the analyses being rapid and efficient.
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Development of sampling for quantification of glyphosate in natural waters
TL;DR: It was found that in the water samples with suspected contamination, the concentration of glyphosate was greater than that permitted by the Ministry of Health, with a percentage coefficient of variation below the allowed limit.
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Electrochemical determination of total reducing sugars from bioethanol production using glassy carbon electrode modified with graphene oxide containing copper nanoparticles
Flávia Camilo Unterman Santos,Leonardo Lataro Paim,José Luiz da Silva,Nelson Ramos Stradiotto +3 more
TL;DR: In this article, the analytical method developed for total reducing sugars determination in residual water samples obtained from sugarcane processing for ethanol production was presented using pulsed amperometry with a glassy carbon electrode modified with graphene oxide containing copper nanoparticles.
References
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Journal ArticleDOI
Limit of detection. A closer look at the IUPAC definition
Gary L. Long,J.D. Winefordner +1 more
Journal ArticleDOI
Nomenclature in evaluation of analytical methods including detection and quantification capabilities (IUPAC Recommendations 1995)
Journal ArticleDOI
Nomenclature in evaluation of analytical methods including detection and quantification capabilities1: (IUPAC Recommendations 1995)
TL;DR: The IUPAC nomenclature document as discussed by the authors has been prepared to help establish a uniform and meaningful approach to terminology, notation, and formulation for performance characteristics of the chemical measurement process (CMP).
Journal ArticleDOI
Detection and quantification limits: origins and historical overview
TL;DR: In this article, the authors present a review of the ISO-IUPAC deliberations and the ensuing harmonized position on concepts and nomenclature, including the meaning and evaluation of sigma, special considerations for calibration (or regression)-based detection and quantification limits, the central role of the blank, and finally some challenges for the future.
Journal ArticleDOI
Validation of chromatographic methods in biomedical analysis viewpoint and discussion
TL;DR: Consistent evaluation of the key analytical parameters: recovery, response function, sensitivity, precision, accuracy, selectivity and stability, is discussed with a view to improving scientific standards in manuscripts submitted for publication.