Journal ArticleDOI
Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
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TLDR
A substantial elevation of the calcitonin gene‐related peptide level in the external jugular but not the cubital fossa blood was seen in both classic and common migraine, and may have importance in the pathophysiology of migraine.Abstract:
The innervation of the cranial vessels by the trigeminal nerve, the trigeminovascular system, has recently been the subject of study in view of its possible role in the mediation of some aspects of migraine. Since stimulation of the trigeminal ganglion in humans leads to facial pain and flushing and associated release of powerful neuropeptide vasodilator substances, their local release into the extracerebral circulation of humans was determined in patients who had either common or classic migraine. Venous blood was sampled from both the external jugular and the cubital fossa ipsilateral to the side of headache. Plasma levels of neuropeptide Y, vasoactive intestinal polypeptide, substance P, and calcitonin gene-related peptide were determined using sensitive radioimmunoassays for each peptide, and values for the cubital fossa and external jugular and a control population were compared. A substantial elevation of the calcitonin gene-related peptide level in the external jugular but not the cubital fossa blood was seen in both classic and common migraine. The increase seen in classic migraine was greater than that seen with common migraine. The other peptides measured were unaltered. This finding may have importance in the pathophysiology of migraine.read more
Citations
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Journal ArticleDOI
Migraine--current understanding and treatment.
TL;DR: The epidemiology, pathophysiology, and preventive and symptomatic treatment of migraine is described, with special attention to drug therapy with the triptans.
Journal ArticleDOI
Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine.
Jes Olesen,Hans-Christoph Diener,Ingo W. Husstedt,Peter J. Goadsby,David E. Hall,Ulrich Meier,Stephane Pollentier,Lynna M. Lesko +7 more
TL;DR: The CGRP antagonist BIBN 4096 BS was effective in treating acute attacks of migraine and showed significant superiority over placebo with respect to most secondary end points.
Journal ArticleDOI
The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
Peter J. Goadsby,Lars Edvinsson +1 more
TL;DR: These data characterize some aspects of the cerebrovascular physiology of the trigeminovascular system and demonstrate important interactions between this system and the effective antimigraine agents sumatriptan and dihydroergotamine and that such interactions can be represented in animal models.
Journal ArticleDOI
Pathophysiology of Migraine: A Disorder of Sensory Processing
Peter J. Goadsby,Philip R. Holland,Margarida Martins-Oliveira,Jan Hoffmann,Christoph J. Schankin,Simon Akerman +5 more
TL;DR: Investment in understanding migraine leaves us at a new dawn, able to transform its impact on a global scale, as well as understand fundamental aspects of human biology.
Journal ArticleDOI
CGRP may play a causative role in migraine
TL;DR: It is suggested that the increase in CGRP observed during spontaneous migraine attacks may play a causative role and cause headache and migraine in migraineurs.
References
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Journal ArticleDOI
Flunarizine in Prophylaxis of Childhood Migraine: A Double-Blind, Placebo-Controlled, Crossover Study
TL;DR: It is concluded that flunarizine is an effective drug for the treatment of childhood migraine and in a study of this length no serious side effects were discovered.
Journal ArticleDOI
Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system
TL;DR: The observation of elevation of substance P—like and CGRP‐like immunoreactivity after activation of the nociceptive afferent system of the head provides new insights into a putative role of peptides in the pathophysiology of migraine and cluster headache, and suggests new areas of possible therapeutic intervention.
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Alpha-1-antitrypsin, autism, and cœliac disease
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Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: trigeminal origin and co-existence with substance P.
TL;DR: The presence of CGRP in the cerebrovascular trigeminal innervation provides further versatility and complexity for this sensory afferent system putatively involved in the transmission of intracranial pain.
Journal ArticleDOI
Headache May Arise From Perturbation of Brain
TL;DR: In this article, the authors report 15 patients who underwent electrode implantation in the periaqueductal gray between 1977 and 1982 who immediately at implantation or in the few days subsequent to implantation reported severe continuous head pain usually with florid "migrainous" feature that persisted for 2 months to 10 years.
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