Visual experience regulates gene expression in the developing striate cortex.
Rachael L. Neve,Mark F. Bear +1 more
TLDR
It is found that the mRNA transcripts of the genes for the neuronal growth-associated protein GAP43, the type II calcium/calmodulin-dependent protein kinase, and glutamic acid decarboxylase are increased in the visual cortex of animals reared in the dark.Abstract:
We have examined the regulation of expression of the genes for the neuronal growth-associated protein GAP43, the type II calcium/calmodulin-dependent protein kinase, and glutamic acid decarboxylase in the kitten visual cortex during normal postnatal development and after a period of visual deprivation. We find that the mRNA transcripts of these genes display very different patterns of normal development but are all increased in the visual cortex of animals reared in the dark. Upon exposure to light, the transcript of the GAP43 gene drops to near-normal levels within 12 hr.read more
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GAP-43: an intrinsic determinant of neuronal development and plasticity.
TL;DR: In transgenic mice, overexpression of GAP-43 leads to the spontaneous formation of new synapses and enhanced sprouting after injury, and the protein might play an important role in mediating experience-dependent plasticity.
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Early organization of the nonlinear right brain and development of a predisposition to psychiatric disorders
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Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex
Daniela Tropea,Gabriel Kreiman,Alvin Lyckman,Alvin Lyckman,Sayan Mukherjee,Sayan Mukherjee,Hongbo Yu,Sam Horng,Mriganka Sur +8 more
TL;DR: DNA microarray analysis with computational approaches, RT-PCR, immunohistochemistry and physiological imaging find that DR leads to upregulation of genes subserving synaptic transmission and electrical activity, consistent with a coordinated response of cortical neurons to reduction of visual drive.
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Levels of the growth-associated protein GAP-43 are selectively increased in association cortices in schizophrenia
Nora I. Perrone-Bizzozero,Angela C. Sower,Edward D. Bird,Larry I. Benowitz,Kathryn J. Ivins,Rachael L. Neve +5 more
TL;DR: It is proposed that schizophrenia is associated with a perturbed organization of synaptic connections in distinct cortical associative areas of the human brain, and that increased levels of GAP-43 are one manifestation of this dysfunctional organization.