Vitamin B12 (cobalamin) deficiency in elderly patients
Emmanuel Andrès,Noureddine Henoun Loukili,Esther Noel,Georges Kaltenbach,Maher Ben Abdelgheni,A.E. Perrin,M. Noblet-Dick,Frédéric Maloisel,Jean-Louis Schlienger,Jean-Frédéric Blicklé +9 more
Reads0
Chats0
TLDR
The epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome, are reviewed, and diagnostic and management strategies for cobalamina deficiency are reviewed.Abstract:
VITAMIN B12 OR COBALAMIN DEFICIENCY occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), pernicious anemia (15%–20% of all cases), insufficent dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobalamin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an emphasis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency.read more
Citations
More filters
Journal ArticleDOI
The human gut microbiome - A potential controller of wellness and disease
Zhi Y. Kho,Sunil K. Lal +1 more
TL;DR: Novel therapies derived from microbiome studies such as fecal microbiota transplantation, probiotic and prebiotics to target associated diseases have been reviewed to introduce the idea of how certain disease symptoms can be ameliorated through dysbiosis correction, thus revealing a new scientific approach toward disease treatment.
Journal ArticleDOI
Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification.
TL;DR: In seniors with low vitamin B-12 status, high serum folate was associated with anemia and cognitive impairment when vitamin B -12 status was normal; when it was normal, however, high Serum folatewas associated with protection against cognitive impairment.
Journal ArticleDOI
Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes.
TL;DR: This work presents the first comprehensive assessment of the B-vitamin synthesis capabilities of the human gut microbiota, and proposes that in addition to diet, the gut microbiota is an important source of B- vitamins, and that changes in the Gut microbiota composition can severely affect the authors' dietary B-Vitamin requirements.
Journal ArticleDOI
Homocysteine‐lowering interventions for preventing cardiovascular events
TL;DR: Whether homocysteine-lowering interventions, provided to patients with and without pre-existing cardiovascular disease are effective in preventing cardiovascular events, as well as reducing all-cause mortality, and to evaluate their safety is evaluated.
Journal ArticleDOI
Elevated Plasma Vitamin B12 Concentrations Are Independent Predictors of In-Hospital Mortality in Adult Patients at Nutritional Risk
Silvia Cappello,Emanuele Cereda,Mariangela Rondanelli,Catherine Klersy,Barbara Cameletti,Riccardo Albertini,Daniela Magno,Marilisa Caraccia,Annalisa Turri,Riccardo Caccialanza +9 more
TL;DR: Although the underlying mechanisms are still unknown and any cause-effect relation cannot be inferred, clinicians should be aware of the potential negative impact of high vitamin B12 concentrations in hospitalized patients at nutritional risk and avoid inappropriate vitamin supplementation.
References
More filters
Book
Wintrobe's clinical hematology.
TL;DR: Wintrobe's clinical hematology is described in more detail in the book Wintrobe: The Anatomy of a Machine, 2nd Ed.
Journal ArticleDOI
Prevalence of cobalamin deficiency in the Framingham elderly population
TL;DR: The prevalence of cobalamin deficiency was > or = 12% in a large sample of free-living elderly Americans, and metabolites correlated best with serum cobalamina values, even when subnormal determinations were excluded.
Journal ArticleDOI
Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician.
TL;DR: In this review, available tests used in the diagnosis of vitamin B12 and folate deficiency are discussed, and a rational approach to thediagnosis of these deficiency states is presented.