Vitamin D and Atopy
TLDR
Vitamin D undergoes the first hydroxylation in the liver to 25-hydroxyvitamin D3 [25(OH)D3], the circulating metabolite, which is what is meant when the term vitamin D is used in this Editorial.About:
This article is published in Clinical Therapeutics.The article was published on 2017-05-01 and is currently open access. It has received 8 citations till now. The article focuses on the topics: Atopy & Vitamin D and neurology.read more
Citations
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Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?
TL;DR: Conditions associated with elevated serum or urine levels of any mast cell mediator, in the absence of comorbidities that could explain elevated levels, should be considered ‘Mast Cell Mediator Disorders (MCMD).’
Journal Article
Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy
TL;DR: The possible roles of vitamin D in the pathogenesis of alopecia areata are discussed in the context of loss of immune privilege in hair follicle, autoreactive effector T cells and mast cells, nature killer group 2 member d-positive cytotoxic T cells, and oxidative stress.
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Ways to Address Perinatal Mast Cell Activation and Focal Brain Inflammation, Including Response to SARS-CoV-2, in Autism Spectrum Disorder
TL;DR: This paper showed that the natural flavonoid luteolin is a potent inhibitor of the activation of both mast cells and microglia, but also blocks SARS-CoV-2 binding to its receptor angiotensin-converting enzyme 2 (ACE2).
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Successful Treatment of a Patient With Severe COVID-19 Using an Integrated Approach Addressing Mast Cells and Their Mediators
TL;DR: In this paper , the authors report on a patient who was initially hospitalized with severe COVID-19 pneumonia as well as physical and mental fatigue, despite having been treated with albuterol, azithromycin, ceftriaxone, dexamethasone, convalescent plasma, and dexamide, her condition continued to worsen to the extent that she was considered for double lung transplant.
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Mold and Immunity.
TL;DR: There are thousands of fungi, but few cause clinically important diseases (mycoses), yet, life-threatening fungal infections are on the rise, especially due to immunocompromised hosts, absence of vaccines against fungi, and the complicated nature of the immune response, which often leads to uncontrollable autoinflammatory storms.
References
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Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
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The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
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The development of allergic inflammation
TL;DR: It is important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reaction.
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Mast cells and inflammation
Theoharis C. Theoharides,Konstantinos-Dionysios Alysandratos,Asimenia Angelidou,Danae A. Delivanis,Nikolaos Sismanopoulos,Bodi Zhang,Shahrzad Asadi,Magdalini Vasiadi,Zuyi Weng,Alexandra Miniati,Dimitrios Kalogeromitros +10 more
TL;DR: Understanding selective release of mediators could explain how mast cells participate in numerous diverse biologic processes, and how they exert both immunostimulatory and immunosuppressive actions.
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Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease
TL;DR: The preclinical findings revealing that vitamin D can regulate catecholamine levels and protect against specific Alzheimer-like pathology increase the plausibility of this link.