Journal ArticleDOI
Water migration from soft gelatin capsule shell to fill material and its effect on drug solubility
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TLDR
The bioavailability of some poorly water-soluble drugs was reported to increase due to a change in dosage form from a tablet to a solution encapsulated in soft gelatin capsules, but the objective of increasing the bioavailability may be defeated if the drug crystallizes from a solution inside the capsule.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1986-01-01. It has received 58 citations till now. The article focuses on the topics: PEG 400 & Dosage form.read more
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Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs
TL;DR: Commercial use of solid dispersion systems during the past four decades has been very limited, primarily because of manufacturing difficulties and stability problems, but this has been changing in recent years because of the availability of surface-active and self-emulsifying carriers and the development of technologies to encapsulate solid dispersions directly into hard gelatin capsules as melts.
Patent
Porous drug matrices and methods of manufacture thereof
Julie Straub,David H. Altreuter,Howard Bernstein,Donald E. Chickering,Sarwat Khattak,Greg Randall +5 more
TL;DR: In this article, low aqueous solubility drugs are provided in a porous matrix form, preferably microparticles, which enhances dissolution of the drug in aaqueous media.
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Self-microemulsifying drug delivery system (SMEDDS) – challenges and road ahead
Shambhu Dokania,Amita Joshi +1 more
TL;DR: Self-microemulsifying drug delivery system (SMEDDS) has emerged as a vital strategy to formulate poor water soluble compounds for bioavailability enhancement but certain limitations are associated with SMEDDS formulations, which restrict their potential usage.
Journal ArticleDOI
Soft gelatin capsules (softgels)
TL;DR: The goal of the current review is to provide an in-depth discussion on the softgel dosage form to formulation scientists who are considering developing softgels for therapeutic compounds.
Patent
Oral Pharmaceutical Dosage Forms
TL;DR: Abuse resistant oral dosage forms suitable for administration of pharmacologically active agents are provided in this paper, where abuse resistant dosage forms are provided for the administration of active agents in the form of capsules.
References
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Solubility of nonelectrolytes in polar solvents.
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A completely absorbed oral preparation of digoxin
TL;DR: Digoxin absorption was studied in healthy volunteers by determination of peak plasma concentrations, areas under plasma concentration curves, and urinary excretion after single‐dose administration and reduced between‐subject variability accompanied the enhanced absorption from capsules.
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Effect of formulation on the bioavailability of retinol, d‐α‐tocopherol and riboflavine
N E Bateman,D A Uccellini +1 more
TL;DR: In this article, a new liquid vehicle (Aqua-biosorb) and encapsulated into soft gelatin capsules was used to investigate factors influencing the bioavailability of vitamins A, E and B2.
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Digoxin bioavailability: formulations and rates of infusions.
TL;DR: There was 21% more digoxin excreted over 6 days after the 3‐hr iv i'lfusion than after the J hr iv infusion, indicating that the calculated bioavailability of an orally administered dose of digoxin may vary with the rapidity of injection of the intravenous standard.
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The solubility of 17 β-oestradiol in aqueous polyethylene glycol 400
M J Groves,B Bassett,V Sheth +2 more
TL;DR: In this paper, the authors measured the solubility of 17 beta-oestradiol (E2) in aqueous solutions of polyethylene glycol (PEG) 400 and found that up to 80% w/w PEG the data conform to a log linear equation ln S = ln Sw + f sigma, where S is the E2 concentration in the water/cosolvent mixture, Sw is E2 solubile in water, f is the weight fraction of PEG 400 and sigma is a parameter representing the cosol