Journal ArticleDOI
Why Does Cisplatin Reach Guanine-N7 with Competing S-Donor Ligands Available in the Cell?
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This article is published in Chemical Reviews.The article was published on 1999-09-08. It has received 720 citations till now. The article focuses on the topics: Guanine.read more
Citations
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Current status of platinum-based antitumor drugs.
Journal ArticleDOI
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo‐ and Stereoselective Hydrogenation of Ketones
Ryoji Noyori,Takeshi Ohkuma +1 more
TL;DR: The newly devised [RuCl(2)(phosphane)(2)(1,2-diamine)] complexes are excellent precatalysts for homogeneous hydrogenation of simple ketones which lack any functionality capable of interacting with the metal center.
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Direct cellular responses to platinum-induced DNA damage
Yongwon Jung,Stephen J. Lippard +1 more
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Metallodrugs in Medicinal Inorganic Chemistry
Katja Dralle Mjos,Chris Orvig +1 more
References
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Journal ArticleDOI
Structure, Recognition, and Processing of Cisplatin-DNA Adducts.
Journal ArticleDOI
Current status of platinum-based antitumor drugs.
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Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation
Anne Marie J. Fichtinger-Schepman,J. L. Van Der Veer,J. H. J. Den Hartog,P. H. M. Lohman,Jan Reedijk +4 more
TL;DR: In kinetic studies on the formation of the various adducts, a clear preference of the Pt compound to react with guanines occurring in the base sequence d(pGpG) was established and the method was used to optimize the digestion conditions for cis-DDP-treated DNA.
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Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin
TL;DR: Information is provided that provides the first crystallographic look at a platinated DNA duplex and should help the design of new platinum and other metal crosslinking antitumour drug candidates and reveals a unique fusion of A- and B-type DNA segments that could be of more general importance.
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Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair.
TL;DR: The anticancer drug cisplatin provokes a complex response in the cell, including some that enhance survival of the cell by mediating DNA repair and others that hasten its death by conferring sensitivity to the drug.