Journal ArticleDOI
Withanolides Q and R, two new 23-hydroxy-steroidal lactones
Reads0
Chats0
TLDR
Two new steroidal lactones of the withanolide type, isolated from Withania somnifera Dun (Solanaceae), are characterized by the unusual presence of a C-23 hydroxy-group.Abstract:
Two new steroidal lactones of the withanolide type, isolated from Withania somnifera Dun (Solanaceae), are characterized by the unusual presence of a C-23 hydroxy-group. Withanolide Q (1a) is (22S,23R)-17α,23,27-trihydroxy-1-oxowitha-2,5,24-trienolide and withanolide R (2a) is (22S,23R)-6α,7α-epoxy-5α,23-dihydroxy-1-oxowitha-2,24-dienolide.read more
Citations
More filters
Book ChapterDOI
Withasteroids, a Growing Group of Naturally Occurring Steroidal Lactones
Anil B. Ray,Mohini Gupta +1 more
TL;DR: Withasteroids are a group of naturally occurring C28-steroidal lactones built on an intact or rearranged ergostane framework and there are many novel structural variants of withanolides with modifications either of the carbocyclic skeleton or of the side chain and these have often been described as modified withanolide-type steroids related towithanolides.
Journal ArticleDOI
Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor.
Manish Kumar Tripathi,Pushpendra Singh,Sujata Sharma,Tej P. Singh,Abdul S. Ethayathulla,Punit Kaur +5 more
TL;DR: The study suggests that Withanoside V in Ashwagandha may be serve as a potential inhibitor against Mpro of SARS-CoV-2 to combat COVID-19 and may have an antiviral effect on nCoV.
Journal ArticleDOI
Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective.
Sumaira Saleem,Gulzar Muhammad,Muhammad Ajaz Hussain,Muhammad Altaf,Syed Nasir Abbas Bukhari +4 more
TL;DR: This review focuses on folk medicinal uses, phytochemistry, pharmacological, and nutrapharmaceutical potential of the versatile plant, which may be attributed to the withanolide alkaloids.
Journal ArticleDOI
Withania somnifera (Linn.) Dunal: a review of chemical and pharmacological diversity
Rishu Kalra,Nutan Kaushik +1 more
TL;DR: The present review summarizes the phytochemical variability and pharmacological advances reported in literature.
Journal ArticleDOI
The treatment of skin carcinoma, induced by UV B radiation, using 1-oxo-5β, 6β-epoxy-witha-2-enolide, isolated from the roots of Withania somnifera, in a rat model
Sheenu Mathur,Parvinder Kaur,Meenakshi Sharma,Anju Katyal,Bharat Singh,Manisha Tiwari,Ramesh Chandra +6 more
TL;DR: Results prove that 1-oxo-5beta, 6beta-epoxy-witha-2-enolide has the potential for acting as an effective agent to prevent the incidence of skin carcinoma induced by UV B radiation.