Wound Healing: Silk Fibroin Biomaterial Shows Safe and Effective Wound Healing in Animal Models and a Randomized Controlled Clinical Trial (Adv. Healthcare Mater. 10/2017)
Wei Zhang,Longkun Chen,Jialin Chen,Lingshuang Wang,Xuexian Gui,Jisheng Ran,Guowei Xu,Hongshi Zhao,Mengfeng Zeng,Junfeng Ji,Li Qian,Jianda Zhou,Hongwei Ouyang,Xiaohui Zou +13 more
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This article is published in Advanced Healthcare Materials.The article was published on 2017-05-01 and is currently open access. It has received 7 citations till now. The article focuses on the topics: Fibroin.read more
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NF-κB signaling is key in the wound healing processes of silk fibroin.
Ye Ri Park,Md. Tipu Sultan,Hyun Jung Park,Jung Min Lee,Hyung Woo Ju,Ok Joo Lee,Dong-Jin Lee,David L. Kaplan,Chan Hum Park +8 more
TL;DR: Using genetic- and protein-level analyses, NF-κB signaling was found to regulate silk fibroin-induced wound healing by modulating target proteins.
Journal ArticleDOI
Multilayered Controlled Drug Release Silk Fibroin Nanofilm by Manipulating Secondary Structure.
TL;DR: This work successfully prepared a controllable secondary structure composed of SF/heparin (HEP) layer-by-layer assembled nanofilms using simple solvents (glycerol and methanol) and investigated the degradation profiles ofSF/HEP nan ofilms depending on their β-sheet contents.
Journal ArticleDOI
Tissue-Adhesive Paint of Silk Microparticles for Articular Surface Cartilage Regeneration.
Jingwei Zhang,Xianzhu Zhang,Yi Hong,Qianbao Fu,Qiulin He,Asma Mechakra,Qiuwen Zhu,Zhou Feifei,Renjie Liang,Chenglin Li,Yejun Hu,Yiwei Zou,Shufang Zhang,Hongwei Ouyang +13 more
TL;DR: JS-Paint treatment showed a significant promotion of cartilage regeneration and restored the smooth joint surface at 6 weeks postsurgery in a rabbit model of a partial-thickness cartilage defect, and revealed that silk fibroin can be utilized to bring about a tissue-adhesive paint.
Journal ArticleDOI
An Off-the-Shelf Tissue Engineered Cartilage Composed of Optimally Sized Pellets of Cartilage Progenitor/Stem Cells
Jisheng Ran,Yang Fei,Canlong Wang,Dengfeng Ruan,Yejun Hu,Zefeng Zheng,Xiao Chen,Zi Yin,Chenqi Tang,Yangwu Chen,Jiayun Huang,Lingfang Shen,lidong wu,Boon Chin Heng,Dominique P. Pioletti,Weiliang Shen,Hongwei Ouyang +16 more
TL;DR: Preliminary data provided preliminary data that the off-the-shell TE cartilage with optimally sized CSPCs pellets seeded within silk scaffolds exhibited strong cartilage repair capacity, which provided a convenient and promising one-step surgical approach to ACI.
Journal ArticleDOI
Cartilage Repair Using Clematis Triterpenoid Saponin Delivery Microcarrier, Cultured in a Microgravity Bioreactor Prior to Application in Rabbit Model.
Pengcheng Tu,Yalan Pan,Chengjie Wu,Guanglu Yang,Xin-Ying Zhou,Jie Sun,Lining Wang,Mengmin Liu,Zhifang Wang,Zhong-Qing Liang,Yang Guo,Yong Ma +11 more
TL;DR: Results provide an alternative preparation method for drug-delivered SF microcarrier and a culture method for maintaining the chondrogenic phenotype of seed cells based on the microgravity environment.