Xanthine Oxidase Inhibitory Activity of Vietnamese Medicinal Plants
Mai Thanh Thi Nguyen,Suresh Awale,Yasuhiro Tezuka,Quan Le Tran,Hiroshi Watanabe,Shigetoshi Kadota +5 more
TLDR
Among 288 extracts, prepared from 96 medicinal plants used in Vietnamese traditional medicine to treat gout and related symptoms, 188 demonstrated xanthine oxidase (XO) inhibitory activity at 100 microg/ml, with 46 having greater than 50% inhibition.Abstract:
Among 288 extracts, prepared from 96 medicinal plants used in Vietnamese traditional medicine to treat gout and related symptoms, 188 demonstrated xanthine oxidase (XO) inhibitory activity at 100 μg/ml, with 46 having greater than 50% inhibition. At 50 μg/ml, 168 of the extracts were active, with 21 possessing more than 50% inhibition. At 25 μg/ml, 146 extracts exhibited inhibitory activity, with 8 showing over 50% inhibition, while 126 extracts presented activity at 10 μg/ml, with 2 having greater than 50% inhibition. The MeOH extracts of Artemisia vulgaris, Caesalpinia sappan (collected at the Seven-Mountain area), Blumea balsamifera (collected in Lam Dong province), Chrysanthemum sinense and MeOH–H2O extract of Tetracera scandens (Khanh Hoa province) exhibited strong XO inhibitory activity with IC50 values less than 20 μg/ml. The most active extract was the MeOH extract of the flower of C. sinense with an IC50 value of 5.1 μg/ml. Activity-guided fractionation of the MeOH extract led to the isolation of caffeic acid (1), luteolin (2), eriodictyol (3), and 1,5-di-O-caffeoylquinic acid (4). All these compounds showed significant XO inhibitory activity in a concentration-dependent manner, and the activity of 2 was more potent (IC50 1.3 μM) than the clinically used drug, allopurinol (IC50 2.5 μM).read more
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References
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Journal ArticleDOI
Structure−Activity Relationship and Classification of Flavonoids as Inhibitors of Xanthine Oxidase and Superoxide Scavengers
Paul Cos,Li Ying,M. Calomme,Jia P. Hu,K. Cimanga,Bart Van Poel,Luc Pieters,A. Vlietinck,Dirk Vanden Berghe +8 more
TL;DR: The structure-activity relationship of flavonoids as inhibitors of xanthine oxidase and as scavengers of the superoxide radical, produced by the action of the enzyme xanthines oxidase, was investigated and showed slightly higher inhibitory activity than flavonols.
Journal ArticleDOI
Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout.
TL;DR: The study demonstrated that the effects for these medicinal plants used for the gout treatment were based, at least in part, on the xanthine oxidase inhibitory action.
Journal ArticleDOI
Carbon-13 NMR studies of flavonoids—I
B. Ternai,K.R. Markham +1 more
TL;DR: In this article, the C-NMR spectra of hydroxylated flavones and flavonols are presented for the first time and the accepted substitution additivity rules have been shown to hold for these compounds except in cases where structural modifications involve the C 3, 4 and 5 positions.
Journal ArticleDOI
Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout
Patrick L. Owen,Timothy Johns +1 more
TL;DR: Xanthine oxidase (xanthine: oxygen oxidoreductase EC 1.3.2) inhibitory activity was assayed from 26 species belonging to 18 families traditionally used for the treatment of gout and related symptoms by Indigenous people of northeastern North America.
Journal ArticleDOI
Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids.
Danny E. C. van Hoorn,Robert J. Nijveldt,Paul A. M. van Leeuwen,Zandrie Hofman,Laura M'Rabet,Dries B.A De Bont,Klaske van Norren +6 more
TL;DR: The data of this study indicate that a planar structure is necessary for high inhibitory activity towards xanthine oxidase, and the contribution of a hydroxyl conjugate turns out to be a constant factor when the natural logarithm of IC(50) values is taken.