Open Access
Xylopia Aethiopica lowers Plasma Lipid Precursors of Reproductive Hormones in Wister Rats
PC Onyebuagu,CP Aloamaka,JC Igweh +2 more
- Vol. 2, Iss: 4, pp 48-53
TLDR
The results suggest that dietary Xylopia aethiopica can induce a reduction in plasma levels of steroid reproductive hormones, possibly through reduction in Plasma cholesterol.Abstract:
This study investigated the effects of dietary Xylopia aethiopica on reproductive hormones and plasma lipids in rats. 10 male and 10 female Wistar rats weighing 200-220g and 120-150g respectively, and subdivided into two respective groups of 5 rats each (M1 and F1 as control; M2 and F2 as test), were used for this study. For 21 days, the control rats received normal feed and clean water ad libitum , while test rats received 50g/kg of feed diet. Blood was collected from the rats and used to determine the reproductive hormone profile and plasma lipids concentration. Hormonal analyses were performed by the ELISA method, while lipid analyses were done using enzymatic saponification for total cholesterol, and enzymatic hydrolysis by lipases for the triglyceride. Results showed that there was a significant decrease (p<0.05) in plasma testosterone concentration (2.70±0.82ng/ml) of the treated male rats. The plasma concentrations of estradiol (13.80±2.84pg/ml) and progesterone (2.85±0.64ng/ml) in the treated females were also significantly reduced. Lipid analyses showed significant reduction in total plasma cholesterol in the treated male rats (1.20±0.63mmol/l) and female rats (1.75±0.55mmol/l). Our results suggest that dietary Xylopia aethiopica can induce a reduction in plasma levels of steroid reproductive hormones, possibly through reduction in plasma cholesterol. Keywords : Xylopia aethiopica, reproductive hormones, plasma lipids.read more
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Effects of Dietary Xylopia aethiopica on Hematological Parameters and Plasma Lipids in Male Wistar Rats
TL;DR: It is concluded that the whole fruits of Xylopia aethiopica exhibited positive effects on blood cell indices and properties, probably by virtue of its rich iron content, and that its reduction in serum total cholesterol is a welcome development as an antihyperlipidemia against the cardiovascular risk factors associated with elevated blood cholesterol levels.
References
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Journal Article
Methods in Enzymology.
TL;DR: This volume is keyed to high resolution electron microscopy, which is a sophisticated form of structural analysis, but really morphology in a modern guise, the physical and mechanical background of the instrument and its ancillary tools are simply and well presented.
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TL;DR: Five groups of steroid hormones are generally recognized according to their physiological behavior: mineralocorticoids, which instruct the renal tubules to retain sodium; glucocortics, which are named for their carbohydratemobilizing properties but have many other effects as well; estrogens, which induce female secondary sexual characteristics; progestins, which is essential for reproduction; and androgens, who induce male secondarySexual characteristics.
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