Does p21 inhibit apoptosis?
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55 Citations | However, an increasing body of information suggests that in addition to its cell-cycle inhibitory activity, p21 can affect p53-dependent apoptosis. |
55 Citations | Taken together our results suggest that p21 induction does not affect the apoptotic response to nongenotoxic p53 activation. |
| In conclusion, our data suggest that overexpression of p21 can promote apoptosis, leading to elevated sensitivity to proapoptotic stimuli. | |
60 Citations | Thus, p21's antiproliferative function is indispensable for the suppression of carcinogenesis from chronically injured liver and renal epithelial cells and cannot be compensated by apoptosis. |
95 Citations | Depending on the stress applied, p21 upregulation can either promote apoptosis or prevent against apoptotic injury. |
45 Citations | Therefore, we hypothesized that overexpression of p21 mediates apoptosis in human VSMC, in addition to the blockade of cell cycle progression. |
27 Citations | The fact that it also occurs in TGCs reveals that p57 and p21 serve nonredundant functions, and suggests that the role of p21 in suppressing apoptosis is restricted to terminally differentiated cells. |
| In conclusion, p21 regulates proliferation and protects against apoptosis in AECs. | |
| In addition, recent data provide strong evidence for new emerging functions of p21, including a role as a modulator of apoptosis. | |
| We speculate that such up-regulation of p21 contributes to the altered pattern of cell growth and resistance to apoptosis. |
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How does p53 affect p21?5 answersStep 1: Answer without citation
P53 affects p21 by forming a complex that influences various cellular functions, including gene expression and stability. The p53/p21 complex is involved in regulating p53-dependent gene expression, and p21 is required for the binding of p53 to the promoters of specific genes. Additionally, p21 negatively regulates p53 stability and promotes the interaction of p53 with Wip1, a phosphatase that facilitates the degradation of p53. Moreover, the p53-p21 pathway can prevent ferroptosis in cancer cells by suppressing the accumulation of toxic lipid ROS and promoting the conservation of the antioxidant glutathione.
Step 3: Answer with citation
P53 affects p21 by forming a complex that influences various cellular functions, including gene expression and stability. The p53/p21 complex is involved in regulating p53-dependent gene expression, and p21 is required for the binding of p53 to the promoters of specific genes. Additionally, p21 negatively regulates p53 stability and promotes the interaction of p53 with Wip1, a phosphatase that facilitates the degradation of p53. Moreover, the p53-p21 pathway can prevent ferroptosis in cancer cells by suppressing the accumulation of toxic lipid ROS and promoting the conservation of the antioxidant glutathione.
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