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Therefore, the activation of coagulation and fibrinolysis during the acute stage of dengue virus infection is offset by the increase of platelet and PAI‐1 during convalescent stage.
Clinical manifestations of thrombocytopenia are not related only to the number of peripheral platelets in dengue infection, but its recovery is associated with clinical improvement.
Nevertheless, hemorrhage in dengue without circulatory collapse is most likely due to activation of platelets rather than coagulopathy, which is well compensated.
C. papaya leaf extract can be considered as a potential candidate for increase in platelet count in patients of dengue, however; there is need of high-quality evidence in the form of large clinical trials before a decision related to the use of such extract is made.
Mean platelet volume is not important as prognostic parameter in dengue fever.