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How the endocytosis of vegfr2 affected by interaction with endoglin?

Kinase insert domain receptor

Sprouting angiogenesis

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Endocytosis of VEGFR2 is influenced by its interaction with endoglin. Endoglin promotes VEGF-induced tip cell formation by interacting with VEGFR2, sustaining it on the cell surface and preventing degradation, crucial for angiogenesis regulation . On the other hand, VEGF induces clathrin-dependent internalization of VEGFR2, where the presence of vascular endothelial cadherin (VEC) at junctions reduces VEGFR-2 signaling by retaining it at the membrane and impeding internalization into signaling compartments . These interactions highlight the intricate regulatory mechanisms governing VEGFR2 endocytosis, crucial for modulating angiogenesis and cell proliferation responses.

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Open access•Journal Article•DOI Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. Maria Grazia Lampugnani, Fabrizio Orsenigo, Maria Cristina Gagliani, Carlo Tacchetti, Elisabetta Dejana, Elisabetta Dejana - Show less +5 more 14 Aug 2006-Journal of Cell Biology 523 Citations	Not addressed in the paper.
Open access•Journal Article•DOI VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF Sean M. Anderson, Bhupinder S. Shergill, Zachary T. Barry, Eleana Manousiouthakis, Tom T. Chen, Elliot L. Botvinick, Manu O. Platt, M. Luisa Iruela-Arispe, Tatiana Segura - Show less +8 more 31 Aug 2011-Integrative Biology 53 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis. Gael Genet, Kevin Boyé, Thomas Mathivet, Roxana Ola, Feng Zhang, Alexandre Dubrac, Jinyu Li, Nafiisha Genet, Luiz Henrique Medeiros Geraldo, Lorena Benedetti, Steffen E. Künzel, Laurence Pibouin-Fragner, Jean-Leon Thomas, Anne Eichmann - Show less +13 more 28 May 2019-Nature Communications 54 Citations	Not addressed in the paper.
Journal Article•DOI Endoglin interacts with VEGFR2 to promote angiogenesis Hongyu Tian, Jennifer J. Huang, Christelle Golzio, Xia Gao, Melissa Hector-Greene, Nicholas Katsanis, Gerard C. Blobe - Show less +6 more 11 Jan 2018-The FASEB Journal 54 Citations	Endoglin interaction with VEGFR2 sustains VEGFR2 on the cell surface, preventing its degradation, thus affecting endocytosis by maintaining VEGFR2 levels for angiogenesis promotion.
Open access•Journal Article•DOI The RALF1-FERONIA interaction modulates endocytosis to mediate control of root growth in Arabidopsis. Meng Yu, Meng Yu, Ruili Li, Ruili Li, Yaning Cui, Yaning Cui, Weijun Chen, Bin Li, Xi Zhang, Yufen Bu, Yangyang Cao, Jingjing Xing, Pawan Kumar Jewaria, Xiaojuan Li, Xiaojuan Li, Rishikesh P. Bhalerao, Rishikesh P. Bhalerao, Feng Yu, Jinxing Lin, Jinxing Lin - Show less +19 more 01 Jan 2020-Development 31 Citations	Not addressed in the paper.

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Related Questions

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Is decreased endocytosis activity associated with cancer?5 answersDecreased endocytosis activity has been associated with cancer. Dysregulation of endocytosis in cancer cells can affect the modulation of cell surface proteins, leading to altered signaling, invasion, migration, survival, and proliferation. Multiple oncogenic alterations have been found to underlie defective endocytosis, including altered ubiquitylation, cytoskeletal interactions, and alterations to Rab family members. Proteogenomic analyses have revealed that driver gene alterations are enriched in the endocytosis pathway in colorectal cancer. Furthermore, endocytosis has been shown to play a role in the control of the cell cycle, mitosis, apoptosis, and cell fate determination, making it deeply ingrained into cell regulation and potentially important in cancer development. Overall, the evidence suggests that decreased endocytosis activity is associated with cancer and may have implications for cancer therapy.

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What is the effect of VEGF on phosphorylation of Tie2?4 answersVEGF has been shown to regulate the phosphorylation of Tie2. It induces proteolytic cleavage and shedding of Tie2 via a PI3K/Akt-dependent pathway. VEGF treatment leads to both constitutive and inducible Tie2 shedding, which is mediated by PI3K/Akt and p38 MAPK. Overexpression of the lipid phosphatase PTEN blocks Tie2 shedding, while overexpression of dominant negative PTEN or constitutively active Akt enhances Tie2 shedding. The shedding of Tie2 by VEGF inhibits angiopoietin-Tie2 signaling, resulting in the inhibition of vascular stabilization and promotion of angiogenesis and vascular remodeling.

Does human VEGF-A activate mouse VEGFR2?5 answersHuman VEGF-A can activate mouse VEGFR2.

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