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Alexandre Dubrac
Researcher at Yale University
Publications - 33
Citations - 1821
Alexandre Dubrac is an academic researcher from Yale University. The author has contributed to research in topics: Angiogenesis & Neovascularization. The author has an hindex of 21, co-authored 32 publications receiving 1269 citations. Previous affiliations of Alexandre Dubrac include University of Toulouse & Centre Hospitalier Universitaire Sainte-Justine.
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Journal ArticleDOI
FGF-dependent metabolic control of vascular development
Pengchun Yu,Kerstin Wilhelm,Alexandre Dubrac,Joe K. Tung,Tiago C. Alves,Jennifer S. Fang,Yi Xie,Jie Zhu,Zehua Chen,Frederik De Smet,Frederik De Smet,Jiasheng Zhang,Suk-Won Jin,Suk-Won Jin,Lele Sun,Hongye Sun,Richard G. Kibbey,Karen K. Hirschi,Nissim Hay,Peter Carmeliet,Thomas Chittenden,Anne Eichmann,Michael Potente,Michael Simons +23 more
TL;DR: FGF-dependent regulation of endothelial glycolysis is a pivotal process in developmental and adult vascular growth and development and FGF receptor (FGFR) signalling is identified as a critical regulator of vascular development.
Journal ArticleDOI
Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch
Irene M. Aspalter,Emma Gordon,Alexandre Dubrac,Anan Ragab,Jarek Narloch,Pedro Vizán,Ilse Geudens,Russell T. Collins,Russell T. Collins,Claudio A. Franco,Cristina Abrahams,Gavin Thurston,Marcus Fruttiger,Ian Rosewell,Anne Eichmann,Anne Eichmann,Holger Gerhardt,Holger Gerhardt,Holger Gerhardt +18 more
TL;DR: This work shows that the heterogeneity between neighbouring endothelial cells established by the lateral feedback loop of Dll4/Notch utilizes Nrp1 levels as the pivot, which in turn establishes differential responsiveness to TGF-β/BMP signalling.
Journal ArticleDOI
Lacteal junction zippering protects against diet-induced obesity
Feng Zhang,Georgia Zarkada,Jinah Han,Jinyu Li,Alexandre Dubrac,Roxana Ola,Gael Genet,Kevin Boyé,Pauline Michon,Pauline Michon,Steffen E. Künzel,Joao Paulo Camporez,Abhishek Singh,Guo-Hua Fong,Michael Simons,Patrick Tso,Carlos Fernández-Hernando,Gerald I. Shulman,William C. Sessa,Anne Eichmann,Anne Eichmann +20 more
TL;DR: Preventing lacteal chylomicron uptake by inducible endothelial genetic deletion of Neuropilin1 (Nrp1) and Vascular endothelial growth factor receptor 1 (Vegfr1) renders mice resistant to diet-induced obesity.
Journal ArticleDOI
Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia
Nicolas Baeyens,Bruno Larrivée,Roxana Ola,Brielle Hayward-Piatkowskyi,Alexandre Dubrac,Billy Huang,Tyler D Ross,Brian Bg Coon,Elizabeth Min,Maya Tsarfati,Haibin Tong,Anne Eichmann,Martin A. Schwartz +12 more
TL;DR: It is reported that fluid flow potentiates BMP activation of Alk1 signaling to stabilize blood vessels and HHT lesions result from a defect in a synergistic mechanical/biochemical signaling pathway.
Journal ArticleDOI
Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization.
Nicolas Rama,Alexandre Dubrac,Thomas Mathivet,Róisín-Ana Ní Chárthaigh,Gael Genet,Brunella Cristofaro,Laurence Pibouin-Fragner,Le Ma,Anne Eichmann,Alain Chédotal +9 more
TL;DR: Conditional knockout mice deficient in various Slit and Robo proteins are generated and it is found that Slit2 potently and selectively promoted angiogenesis via Robo1 and Robo2 in mouse postnatal retina and in a model of ocular neovascular disease.