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How to increase estrogen and progesterone to get pregnant? 

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The results demonstrate that RJ treatment in conjunction with a source of exogenous progesterone can be used to induce estrus and increase first service conception rate in sheep.
This “facilitating” effect of progesterone is thought to act synergistically with the initial “priming” effect of estrogen.
HRT optimization can thus be achieved by combining low doses of estrogen given transdermally with micronized oral progesterone; such optimized HRT will allow us to treat symptomatic women for as long as required.
Elucidating a mechanism to decrease progesterone catabolism, thereby increasing embryonic and uterine exposure to progesterone, seems a logical approach to ameliorate high rates of embryonic loss.
Thus, these experiments demonstrate that a defined estrogen priming is required for the positive feedback effect of progesterone on the gonadotropin release in eugonadal women.
This, coupled with an increase in 3 beta-HSD may explain the pre-ovulatory increase in progesterone seen in many species.
These studies support the hypothesis that in the estrogen-primed rat, progesterone facilitates the induction of the gonadotropin surge by maintaining hypothalamic synthesis of NPY as well as by modulating anterior pituitary NPY tissue levels.
Other studies in intact women and monkeys have indicated that progesterone (P) may facilitate estrogen induction of the preovulatory gonadotropin surges.
The results in this study suggest that progesterone may be one regulator in the local conversion of estrogen precursors into potent estradiol in normal breast tissue.
These results provide a basis for determining the direct role of estrogen and progesterone in preimplantation embryos.