Charlotta Dabrosin

TL;DR: 10 important aspects of tumor angiogenesis and the pathological tumor vasculature which would be well suited as targets for anti-angiogenic therapy are identified and 10 plant-derived compounds could be combined to constitute a broader acting and more effective inhibitory cocktail at doses that would not be likely to cause excessive toxicity.

TL;DR: The potential use of resveratrol as a chemotherapeutic agent in breast cancers is supported by the observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ERalpha- ERbeta+ MDA-MB-231 tumors in resver atrol-treated nude mice compared with controls.

TL;DR: An international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broad-spectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms, and results suggest that a broad-spectrums approach should be feasible from a safety standpoint.

TL;DR: New light is shed on the mechanisms underlying the progression of ER+ breast cancer and the potential of novel therapies targeting CCL2 and CCL5 pathways is indicated.

TL;DR: The results suggest that flaxseed and its lignans have potent antiestrogenic effects on estrogen receptor–positive breast cancer and may prove to be beneficial in breast cancer prevention strategies in the future.