Was the Spanish flu an RNA virus?
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|---|---|
100 Citations | Thus, the Spanish Flu virus resembles avian influenza A viruses in its ability to recruit Crk/CrkL to modulate host cell signaling. |
19 Citations | This was later supported by the finding that MVV is an RNA virus. |
231 Citations | Influenza virus is a negative strand RNA virus and is one of the rare RNA viruses to replicate in the nucleus. |
34 Citations | Along with previous reports, our data propose that influenza A virus uses a redundant and plastic network of RNA-RNA and potentially RNA-nucleoprotein interactions to coordinately incorporate its segmented genome into virions. |
| Influenza virus is thus unique among nononcogenic RNA viruses in synthesizing its mRNA in the nucleus. | |
| (1) identifies virus-encoded, short RNAs (svRNA) as a component of the influenza A viral replicase and an essential prerequisite for viral RNA synthesis. | |
| Although a great deal of evidence indicates that the 1918 A(H1N1) influenza virus unlikely originated in and spread from Spain, the 1918-1919 influenza pandemic will always be known as the Spanish flu. | |
26 Citations | This sedimentation pattern corresponds closely to that of incomplete influenza virus RNA. |
35 Citations | Taken together, these data suggest that HA and the viral RNA polymerase complex are critical determinants of Spanish influenza pathogenesis, but only HA, and not the viral RNA polymerase complex and NP, is responsible for extreme host responses observed in mice infected with the 1918 influenza virus. |
145 Citations | They further imply that the observed insensitivity of the 1918 virus-based replicon to the antiviral activity of human MxA is a hitherto unrecognized characteristic of the “Spanish flu” virus that may contribute to the high virulence of this unusual pandemic strain. |
Related Questions
What is the origin of the Spanish flu?5 answersThe origin of the Spanish flu remains controversial, with some experts suggesting it emerged and circulated in the population before March 1918 in America, while others propose a European origin. The virus was associated with the soldiers who fought during World War I, as the military camps and trenches provided the ideal conditions for the virus to develop and spread. Recent research has shown that the 1918 pandemic virus contains genes derived from avian-like influenza virus strains, and it is the common ancestor of human and classical swine H1N1 influenza viruses. The name "Spanish Flu" is a misnomer, as the first appearance of the virus was in the United States, not Spain. The high mortality in the 20-40 age group remains an enigma, with some experts suggesting reduced immune response in patients previously exposed to related viral hemagglutinins during the 1889 pandemic.
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