What are advancements in engineering Beta-Amyloid for Alzheimer disease?
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Engineering Beta-Amyloid for Alzheimer's disease has seen advancements through various approaches. Studies have explored utilizing two-dimensional covalent organic frameworks (COFs) to prevent Beta-Amyloid aggregation, showing potential in inhibiting protofibril self-assembly and fibrillation . Additionally, novel structures based on MBenes like Cd2B have demonstrated effectiveness in destabilizing Beta-Amyloid structures, paving the way for potential medicinal agents to prevent amyloid-β accumulation . Furthermore, research on transgenic mouse models has led to the development of App knock-in mice, providing insights into Aβ metabolism, clearance, and the differential roles of enzymes involved in Aβ degradation . These advancements offer promising avenues for future experimental research and therapeutic strategies in combating Alzheimer's disease.
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5 Citations | Not addressed in the paper. |
5 Citations | Novel bioengineered MBenes like Cd2B show promise in destabilizing Beta-amyloid structures, potentially preventing accumulation in Alzheimer's disease, as per the in-silico study findings. |
| Recent advancements include developing App knock-in mice models like App G-F devoid of Swedish mutations for preclinical studies on β-secretase inhibitors, enhancing research on Alzheimer's disease treatment strategies. | |
18 Citations | Amine-functionalized COFs with large surface area prevent beta-amyloid aggregation, inhibit protofibril self-assembly, enhance diffusivity through the BBB, and destabilize amyloid structure, offering potential Alzheimer's treatment advancements. |
| Not addressed in the paper. |
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