What are sulfonamides?
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Sulfonamides are versatile compounds with significant applications in various fields. They are crucial motifs in antibiotics, chemosensors for detecting ionic species optically, and xenobiotic pollutants in the environment. Sulfonamides have been extensively studied for their synthesis, medical properties, resistance mechanisms in bacteria, and potential as drug candidates against viral infections. These compounds can easily undergo chemical modifications, making them valuable in drug design and discovery. Additionally, sulfonamides exhibit diverse biological activities beyond antibacterial effects, including antiviral properties against viruses like SARS-CoV-2 and HIV. Their ability to form hydrogen bonds and interact within proteins underscores their potential as molecular chimeras for developing new therapeutic entities. Overall, sulfonamides play a crucial role in pharmaceuticals, environmental science, and analytical chemistry. .
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25 Citations | Sulfonamides are the oldest synthetic antibiotics still in use, widely contaminating the environment. Bacteria exhibit resistance mechanisms, co-metabolic transformation, and mineralization of sulfonamides. |
| Sulfonamides are key components in antiviral drugs, synthesized with heterocyclic structures, exhibiting broad-spectrum antiviral activity against viruses like SARS-CoV-2, HIV, and more. | |
| Sulfonamides are a class of antibiotics, including N-acylsulfonamide, used for over 80 years despite drug resistance. They are essential in designing new sulfa drug analogues. | |
| Sulfonamides are significant in drug design due to their versatility for chemical modifications, potentially leading to improved drugs, acting as "molecular chimera" forming hydrogen bonds in proteins. | |
3 Citations | Sulfonamides are optical chemosensors that bind with ionic species through various mechanisms, producing optical changes detectable in visible or UV light, making them valuable in analytical chemistry applications. |
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