What are the cellular impact of a myocardial infarction ?
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Following a myocardial infarction (MI), various cellular impacts are observed. The repair process post-MI involves three overlapping phases: the inflammatory phase, proliferative phase, and maturation phase, where immune cells like macrophages, neutrophils, and lymphocytes play crucial roles in governing these phases . Additionally, studies highlight the emergence of different cellular phenotypes in the infarcted heart, such as senescent cells, inflammatory cells, and dedifferentiated cardiomyocytes, which contribute to adverse remodeling and impaired healing post-MI . Single-cell RNA sequencing data in murine hearts post-MI revealed immune cell heterogeneity, with distinct proinflammatory and prophagocytic capabilities in macrophages, and sequential cell-fate transitions in neutrophils, indicating complex transcriptional profiles and pathways post-MI . Understanding these cellular impacts is crucial for developing targeted therapies to prevent heart failure after MI.
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| The impact of a myocardial infarction includes temporal changes in immune cell functions, involving macrophages, neutrophils, and lymphocytes, influencing cardiac repair and potential heart failure development. | |
| Myocardial infarction leads to immune cell infiltration, with distinct macrophage subsets showing proinflammatory or prophagocytic capabilities, and neutrophils exhibiting sequential activation states in the ischemic heart. | |
2 Citations | The paper discusses the impact of myocardial infarction on immune cell dynamics, specifically macrophages, neutrophils, and lymphocytes, during the repair process. |
19 Citations | The paper discusses the cellular phenotypes and pathways implicated in injury, remodeling, and regeneration of the myocardium after myocardial infarction. |
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