M
Motoaki Sano
Researcher at Keio University
Publications - 250
Citations - 14298
Motoaki Sano is an academic researcher from Keio University. The author has contributed to research in topics: Heart failure & Medicine. The author has an hindex of 55, co-authored 230 publications receiving 12192 citations. Previous affiliations of Motoaki Sano include Tokai University & Chugai Pharmaceutical Co..
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Journal ArticleDOI
Cardiomyocytes can be generated from marrow stromal cells in vitro
Shinji Makino,Keiichi Fukuda,Shunichirou Miyoshi,Fusako Konishi,Hiroaki Kodama,Jing Pan,Motoaki Sano,Toshiyuki Takahashi,Shingo Hori,Hitoshi Abe,Jun-ichi Hata,Akihiro Umezawa,Satoshi Ogawa +12 more
TL;DR: Analysis of the isoform of contractile protein genes, such as myosin heavy chain, myos in light chain, and alpha-actin, indicated that their muscle phenotype was similar to that of fetal ventricular cardiomyocytes.
Journal ArticleDOI
Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes.
Shugo Tohyama,Fumiyuki Hattori,Motoaki Sano,Takako Hishiki,Yoshiko Nagahata,Tomomi Matsuura,Hisayuki Hashimoto,Tomoyuki Suzuki,Hiromi Yamashita,Yusuke Satoh,Toru Egashira,Tomohisa Seki,Naoto Muraoka,Hiroyuki Yamakawa,Yasuyuki Ohgino,Tomofumi Tanaka,Masatoshi Yoichi,Shinsuke Yuasa,Mitsushige Murata,Makoto Suematsu,Keiichi Fukuda +20 more
TL;DR: A nongenetic method for mass-producing cardiomyocytes from mouse and human PSC derivatives that is based on the marked biochemical differences in glucose and lactate metabolism between cardiomers and noncardiomyocyte and could facilitate progress toward PSC-based cardiac regenerative therapy.
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Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction.
Xiaoxiang Yan,Atsushi Anzai,Yoshinori Katsumata,Tomohiro Matsuhashi,Kentaro Ito,Jin Endo,Tsunehisa Yamamoto,Akiko Takeshima,Ken Shinmura,Weifeng Shen,Keiichi Fukuda,Motoaki Sano,Motoaki Sano +12 more
TL;DR: Timely reperfusion reduced the total number of leukocytes accumulated in the post-MI period, shifting the peak of innate immune response towards earlier and blunting the wave of adaptive immune response.
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Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury.
Kentaro Hayashida,Motoaki Sano,Motoaki Sano,Ikuroh Ohsawa,Ken Shinmura,Kayoko Tamaki,Kensuke Kimura,Jin Endo,Takaharu Katayama,Akio Kawamura,Shun Kohsaka,Shinji Makino,Shigeo Ohta,Satoshi Ogawa,Keiichi Fukuda +14 more
TL;DR: Inhalation of H(2) gas is promising strategy to alleviate ischemia-reperfusion injury coincident with recanalization of coronary artery, thereby preventing deleterious left ventricular remodeling.
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Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle
Noriaki Shimizu,Noritada Yoshikawa,Naoki Ito,Takako Maruyama,Yuko Suzuki,Sin Ichi Takeda,Jun Nakae,Yusuke Tagata,Shinobu Nishitani,Kenji Takehana,Motoaki Sano,Keiichi Fukuda,Makoto Suematsu,Chikao Morimoto,Hirotoshi Tanaka +14 more
TL;DR: It is shown that direct target genes of the glucocorticoid receptor (GR) in skeletal muscle, i.e., REDD1 and KLF15 inhibits mTOR activity, but via a distinct mechanism involving BCAT2 gene activation, and GR is a liaison involving a variety of downstream molecular cascades toward muscle atrophy.