What are the effect of LPS infusions in terms of effect in microglia, astrocyte and cytokines?
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Lipopolysaccharide (LPS) infusions induce significant effects on microglia, astrocytes, and cytokines. LPS administration triggers microglial activation and alters their morphology, leading to synaptic dysfunction and cognitive impairment over a defined temporal sequence . Additionally, LPS exposure results in the activation of glial-specific genes, particularly in microglia, and induces differential alternative splicing in astrocytes, affecting immune-specific responses . Furthermore, LPS injections lead to peripheral and central increases in pro-inflammatory cytokines, impacting microglia activation in a strain and sex-dependent manner . Overall, LPS infusion disrupts the neurovascular unit by affecting the interactions between perivascular astrocytes and microglia, contributing to neuroinflammation and potential blood-brain barrier integrity loss .
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| Papers (5) | Insight |
|---|---|
| LPS infusions activate microglia, increase inflammatory cytokines (IL-6, TNF-α), and decrease dopaminergic neurons, contributing to depression in a Parkinson's disease-like condition. Astrocytes were not specifically mentioned. | |
25 Citations | LPS infusions induce strain and sex-dependent changes in microglia activation, astrocyte percentage, and cytokine levels, particularly TNF-α, IL-1β, and IL-6 in male mice. |
| LPS infusions induce microglial activation, GABAergic synaptic deficits, and prolonged cognitive impairment, but the effects on astrocytes and cytokines are not specifically addressed in the paper. | |
| LPS infusion triggers microglial and astrocytic activation, altering their interactions with vasculature, potentially compromising BBB integrity. Cytokines like IL-1a, TNFa, and C1q play key roles in this process. | |
| LPS infusions impact microglia and astrocytes, with Ptbp1 exon 8 skipping modulating immune response. Alternative splicing affects immune-related genes, suggesting a role in brain immune modulation. |
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