What are the effects of graphene oxide on gap junction protein expression?
Graphene oxide (GO) has been shown to have effects on the expression of gap junction proteins. In a study by Nakashima et al., it was found that the expression of the gap junction protein connexin (Cx) 32 decreased as hepatocellular carcinoma (HCC) progressed, suggesting a potential role of Cx32 in hepatocarcinogenesis . Another study by Rudnytska et al. demonstrated that GO treatment led to the up-regulation of key regulatory genes involved in cell proliferation, such as TOB1, HSPA5, EDEM1, MYBL1, and MYBL2, in normal human astrocytes . Ghazimoradi et al. reviewed the epigenetic alterations caused by GO, including changes in DNA methylation, histone modification, and altered expression of non-coding RNAs . Additionally, de Lázaro and Kostarelos found that exposure to GO resulted in significant deviations in the expression of various reference genes, including ribosomal proteins, which are crucial for appropriate qPCR data normalization . Overall, these studies suggest that GO can affect the expression of gap junction proteins and other regulatory genes, potentially impacting cellular processes and disease progression.
Answers from top 5 papers
| Papers (5) | Insight |
|---|---|
3 Citations | The effects of graphene oxide on gap junction protein expression are not mentioned in the provided paper. The paper focuses on the epigenetic alterations caused by graphene oxide, such as DNA methylation, histone modification, and altered expression of non-coding RNAs. |
| The effects of graphene oxide on gap junction protein expression are not mentioned in the provided paper. The paper focuses on the impact of graphene oxide on the expression of key regulatory genes and microRNAs in normal human astrocytes. | |
58 Citations | The effects of graphene oxide on gap junction protein expression are not mentioned in the provided paper. The paper is about the expression of the gap junction protein connexin32 in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. |
21 Sep 2022 | The effects of graphene oxide on gap junction protein expression are not mentioned in the provided paper. The paper focuses on the expression of gap junction proteins in neonatal rat lung tissue exposed to hyperoxia. |
8 Citations | The effects of graphene oxide on gap junction protein expression are not mentioned in the provided paper. |