What are the roles of receptor tyrosine kinases in breast cancer?
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Receptor tyrosine kinases (RTKs) play important roles in breast cancer. They are involved in the regulation of cell signaling pathways that contribute to cancer development and metastasis. RTKs respond to environmental cues by initiating signaling cascades in tumor cells, including pathways such as MAPK, PI3K/Akt, and JAK/STAT . Aberrant activation of RTKs can lead to the acquisition of genetic and epigenetic changes in cancer cells, making them amenable to therapy . RTKs, such as EGFR, HER2, and HER3, are overexpressed in breast cancer and are targeted by monoclonal antibodies and tyrosine kinase inhibitors . RTKs are also involved in angiogenesis, which is crucial for tumor growth and progression . Additionally, the tyrosine kinase-independent functions of RTKs, such as DDR2, can support tumor invasion and metastasis . Overall, RTKs have diverse roles in breast cancer and represent potential therapeutic targets for intervention.
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| Papers (5) | Insight |
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| The roles of receptor tyrosine kinases (RTKs) in breast cancer include regulating downstream signaling pathways, promoting tumor growth, angiogenesis, metastasis, cancer stemness, and drug resistance. | |
6 Citations | The paper discusses the role of the receptor tyrosine kinase (RTK) discoidin domain receptor 2 (DDR2) in breast cancer metastasis, but it does not provide information on the roles of other RTKs in breast cancer. |
| The provided paper does not specifically mention the roles of receptor tyrosine kinases in breast cancer. | |
30 Citations | The provided paper does not specifically mention the roles of receptor tyrosine kinases in breast cancer. |
| The paper does not provide information about the specific roles of receptor tyrosine kinases in breast cancer. |
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