What is intrauterine drug delivery?
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10 Citations | While the vaginal application of the drug is apparently less effective than the intrauterine (1), it has the advantage of simple delivery and the potential of self-administration. |
26 Citations | These data indicate that ELP does not cross the placenta, and they suggest that this adaptable drug delivery system is a promising platform for prevention of fetal drug exposure. |
19 Citations | Vaginal drug delivery represents an attractive strategy for local and systemic delivery of drugs otherwise poorly absorbed after oral administration. |
| Therefore, this new drug delivery system addresses the problems of conventional intravesical instillation and is promising for clinic use. | |
| The fetal exposure to, and neonatal burden at delivery of, drugs administered during labour and delivery may be influenced by many factors, including maternal posture, mode of drug administration, the drug administration to delivery interval, fetal pH, and whether intravenous bolus drug administration coincides with the contraction or relaxation phase of uterine activity. |
Related Questions
What are the long-term effects of using an intra-uterine device (IUD) on fertility and reproductive health?5 answersLong-term use of intrauterine devices (IUDs) can have various effects on fertility and reproductive health. Complications such as pelvic inflammatory disease (PID), expulsion, and contraception failure have been reported in some cases. Additionally, IUDs may lead to the formation of bladder stones due to migration of the device, requiring surgical intervention for removal. However, postpartum IUDs have been shown to be safe and effective in preventing unintended pregnancies, with low rates of device-related pregnancies and rare occurrences of expulsions, abnormal bleeding, infections, or perforations. It is essential to consider both the benefits and risks associated with long-term IUD use when evaluating its impact on fertility and reproductive health.
What are the limitations of current intraoral drug delivery approaches?5 answersCurrent intraoral drug delivery approaches have several limitations. One major limitation is the low drug concentration absorbed in the buccal mucosa, which hinders achieving an acceptable therapeutic effect. This is primarily due to factors such as saliva turnover, tongue and masticatory movements, phonation, enzymatic degradation, and lack of epithelium permeation. Another limitation is the physicochemical barriers encountered by lipid-based nanocarriers along the gastrointestinal tract, including the gastric acidic content, intestinal mucus layer, and enzymatic degradation. These barriers pose challenges to achieving efficient oral drug delivery through lipid-based nanocarriers. Additionally, conventional oral drug delivery systems face difficulties such as inappropriate drug release and reduction in efficacy, leading to decreased drug delivery effectiveness. Furthermore, oral delivery of anticancer drugs faces limitations due to their idiosyncratic physicochemical properties and biological barriers, such as pre-systemic metabolism and gastrointestinal instability. These limitations highlight the need for innovative approaches to overcome the challenges associated with current intraoral drug delivery methods.
What are the most effective treatments for dysmenorrhea?5 answersNon-steroidal anti-inflammatory drugs (NSAIDs) and vasopressin receptor antagonists are two forms of treatment for primary dysmenorrhea. Studies on the effectiveness of NSAIDs have consistently shown positive results, making them a reliable treatment option. However, research on vasopressin receptor antagonists has yielded contradictory results, and their clinical efficacy remains inconclusive. Other promising novel treatments for primary dysmenorrhea include levonorgestrel-releasing intrauterine devices, intravaginal rings, and transdermal patches, but further studies are needed to validate their efficacy. In addition to pharmacological treatments, complementary and alternative medicine approaches such as exercise, acupuncture, and herbal preparations have shown some effectiveness, but more research is needed. Overall, NSAIDs are currently the most effective and reliable treatment option for primary dysmenorrhea, while other treatments require further investigation and validation.
What are the effects of intrauterine devices on body weight?5 answersIntrauterine devices (IUDs) have been studied for their effects on body weight. However, none of the abstracts provided specifically address the effects of IUDs on body weight. Therefore, there is no information available from the abstracts to answer the question about the effects of IUDs on body weight.
Is immediate postpartum insertion of intrauterine Cu IUD associated with higher rate of unintended pregnancy?5 answersImmediate postpartum insertion of intrauterine Cu IUD is associated with a higher risk of expulsion compared to interval insertion. However, the benefits of immediate postpartum IUD insertion, such as improved rates of contraception continuance and reduced instances of short interval birth, outweigh this risk. Studies have shown that immediate postpartum initiation of long-acting reversible contraception (LARC) methods, including IUDs, leads to increased utilization of LARC and prevention of unintended pregnancies. Immediate postpartum IUD insertion is safe and effective, with a majority of IUD devices retained at 6 and 12 months. While there is an increased risk of expulsion compared to delayed postpartum insertion and interval insertion, this needs to be weighed against the risk of patients not returning for postpartum follow-up. Overall, immediate postpartum insertion of intrauterine Cu IUD is a valuable contraceptive option, but careful consideration should be given to individual patient factors and preferences.
What contraception prevents sperm from entering the uterus?5 answers