What is the current state of research on the use of iron oxide nanoparticles in cancer therapy?
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Iron oxide nanoparticles (IONPs) have shown promise in cancer therapy. One approach is chemodynamic therapy (CDT), which utilizes a Fenton/Fenton-like reaction to generate hydroxyl radicals for tumor cell killing . Another approach is the use of superparamagnetic IONPs for hyperthermia-based therapy, where laser irradiation raises the temperature of IONP dispersions, leading to cancer cell death . Additionally, IONPs can be loaded into hydrogels for photothermal therapy (PTT), where they mediate PTT under near-infrared laser irradiation, effectively killing cancer cells . Furthermore, the application of rotating magnetic fields (RMFs) has been investigated to enhance the intracellular uptake of IONPs, improving their therapeutic efficacy in magnetic hyperthermia . Finally, the development of doxorubicin-loaded liposomal IONPs has shown potential for combined chemo-photothermal cancer therapy, with increased tumor accumulation and greater photothermal effects . Overall, these studies demonstrate the diverse applications of IONPs in cancer therapy, including CDT, hyperthermia-based therapy, PTT, and combined chemo-photothermal therapy.
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| Papers (5) | Insight |
|---|---|
| The paper discusses the development of liposomal iron oxide nanoparticles loaded with doxorubicin for combined chemo-photothermal cancer therapy. It does not provide information on the current state of research on the use of iron oxide nanoparticles in cancer therapy. | |
| The paper discusses the use of superparamagnetic iron oxide nanoparticles (SPIONs) in cancer therapy, specifically focusing on enhancing their intracellular uptake through the application of rotating magnetic fields (RMFs). | |
| The paper discusses the development of iron oxide (Fe3O4) nanoparticle-loaded hydrogels for photothermal therapy of colorectal cancer cells. It does not provide information on the current state of research on the use of iron oxide nanoparticles in cancer therapy beyond the scope of the study. | |
| The current state of research on the use of iron oxide nanoparticles in cancer therapy is focused on combining ion interference therapy (IIT) and chemodynamic therapy (CDT) to enhance the efficiency of CDT and promote the generation of reactive oxygen species (ROS). | |
| The current state of research on the use of iron oxide nanoparticles in cancer therapy is discussed in the provided paper. |
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