What is the fate of estrogen and progesterone?
Answers from top 7 papers
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| Papers (7) | Insight |
|---|---|
| This observation indicates that progesterone modulates the action of estrogen by controlling nuclear retention of the estrogen-receptor complex. | |
48 Citations | The requirement for maintenance of a background level of estrogen suggests that the inhibitory action of progesterone is mediated through progesterone receptor interactions. |
15 Citations | Furthermore, our observations are in keeping with the finding that progesterone has little or no effect at the organismal or tissue level unless estrogen is present. |
1.7K Citations | In most cases the PR is induced by estrogen, implying that many of the in vivo effects attributed to progesterone could also be the result of concomitantly administered estrogen. |
| The results indicate a critical temporal reliance of the inhibitory effects of progesterone on estrogen receptor activity and estrogen function in a well defined animal model. | |
47 Citations | We conclude that progesterone acts at a point beyond estrogen receptor availability or translocation to antagonize estrogen action. |
36 Citations | These results suggest a mechanism for antagonistic effects of estrogen and progesterone. |
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